ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Brain-derived neurotrophic factor modulates the development of the dopaminergic network in the rodent retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 93 citations in OpenAlex.
- Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus.Frontiers in cellular neuroscience · 2025Article
- Dopaminergic amacrine cell number, plexus density, and dopamine content in the mouse retina: Strain differences and effects of Bax gene disruption.Experimental eye research · 2018Article
- The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury.PloS one · 2017Article
- Efficacy and Safety of Human Retinal Progenitor Cells.Translational vision science & technology · 2016Article
- Lack of netrin-4 modulates pathologic neovascularization in the eye.Scientific reports · 2016Article
- Conjunctivally Applied BDNF Protects Photoreceptors from Light-Induced Damage.Translational vision science & technology · 2015Article
- Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness.International journal of nanomedicine · 2015Review
- Neuroprotective and antiapoptotic activity of lineage-negative bone marrow cells after intravitreal injection in a mouse model of acute retinal injury.Stem cells international · 2015Article
- A three-way parallel ICA approach to analyze links among genetics, brain structure and brain function.NeuroImage · 2014Article
- Article
- The γ3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies.Matrix biology : journal of the International Society for Matrix Biology · 2012Article
- The expression and function of netrin-4 in murine ocular tissues.Experimental eye research · 2012Article
- Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days.PloS one · 2012Article
- Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice.Toxicology and applied pharmacology · 2011Article
- Overexpression of neurotrophin-3 stimulates a second wave of dopaminergic amacrine cell genesis after birth in the mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Non-centered spike-triggered covariance analysis reveals neurotrophin-3 as a developmental regulator of receptive field properties of ON-OFF retinal ganglion cells.PLoS computational biology · 2010Article
- Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development.Journal of anatomy · 2010Article
- Setting the pace for retinal development: environmental enrichment acts through insulin-like growth factor 1 and brain-derived neurotrophic factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Retinal TrkB receptors regulate neural development in the inner, but not outer, retina.Molecular and cellular neurosciences · 2008Article
- Brain-derived neurotrophic factor and TrkB modulate visual experience-dependent refinement of neuronal pathways in retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopaminergic cells in the retina express the receptor for brain-derived neurotrophic factor (BDNF) (). To investigate whether BDNF can influence the development of the retinal dopaminergic pathway, we performed intraocular injections of BDNF during the second or third postnatal week and visualized the dopaminergic system with tyrosine hydroxylase (TH) immunohistochemistry. Both regimens of BDNF treatment caused an increase in TH immunoreactivity in stratum 1 and stratum 3 of the inner plexiform layer (IPL). D2 dopamine receptor immunoreactivity, a presynaptic marker of dopaminergic cells (), was also increased in stratum 1 and stratum 3 of the inner plexiform layer. These data suggest that BDNF causes sprouting of dopaminergic fibers in the inner plexiform layer. Other neurochemical systems, for example, the cholinergic amacrine cells, remained unaffected. Similar effects were observed after injections of neurotrophin-3 and neurotrophin-4, but not nerve growth factor. Analysis of whole-mounted TH-immunolabeled retinae revealed hypertrophy of dopaminergic cells (+41% in soma areas; p < 0.01) and an increase of labeled dopaminergic varicosities in stratum 1 of the IPL (+51%; p < 0.01) after BDNF treatment. The opposite was observed in mice homozygous for a null mutation of the bdnf gene: dopaminergic cells were atrophic (-22.5% in soma areas; p < 0.05), and the density of TH-positive varicosities in stratum 1 was reduced (57%; p < 0.01). We conclude that BDNF controls the development of the retinal dopaminergic network and may be particularly important in determining the density of dopaminergic innervation in the retina.
Indexed as
Identifiers
9547243PMC6792644W2117590912What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.