ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Bcl-2 accelerates the maturation of early sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- The Potential Mechanism of Eriodictyol in Treating Alzheimer's Disease: A Study on Computer-assisted Investigational Strategies.Current pharmaceutical design · 2024Article
- Driving apoptosis-relevant proteins toward neural differentiation.Molecular neurobiology · 2012Review
- Where and what is the paralaminar nucleus? A review on a unique and frequently overlooked area of the primate amygdala.Neuroscience and biobehavioral reviews · 2012Review
- Bcl2 enhances induced hematopoietic differentiation of murine embryonic stem cells.Experimental hematology · 2008Article
- Muller cell expression of glutamate cycle related proteins and anti-apoptotic proteins in early human retinal development.The British journal of ophthalmology · 2006Article
- Morphometric analysis of embryonic rat trigeminal neurons treated with different neurotrophins.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2004Article
- Bcl-2 immunoreactive neurons are differentially distributed in subregions of the amygdala and hippocampus of the adult macaque.Neuroscience · 2004Article
- Medulloblastoma with extensive nodularity: a variant occurring in the very young-clinicopathological and immunohistochemical study of four cases.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2004Article
- Bcl-2 mediates induction of neural differentiation.Oncogene · 2003Article
- Newly generated neurons in the amygdala and adjoining cortex of adult primates.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons.The Journal of cell biology · 2000Article
- Optic nerve crush: axonal responses in wild-type and bcl-2 transgenic mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bcl-2 is a cytoplasmic protein that blocks apoptosis in a wide variety of cell types. Here we report a novel role for Bcl-2 in the early stages of neuronal development. Shortly after differentiating from progenitor cells, sensory neurons undergo a distinct morphological change; initially they have small, spindle-shaped, phase-dark cell bodies that become large, spherical, and phase-bright. Early sensory neurons cultured from the trigeminal ganglia of bcl-2-/- embryos at embryonic day 11 (E11) and E12 underwent this change more slowly than trigeminal neurons of wild-type embryos of the same ages. The delay was not attributable to the well documented role of Bcl-2 in preventing apoptosis, because Bcl-2-deficient early sensory neurons survived as well as wild-type neurons. Accordingly, there was a significantly smaller number of the more mature type of neuron in the early trigeminal ganglia of bcl-2-/- embryos, yet the number of neurons in the trigeminal ganglia of bcl-2-/- and wild-type embryos was similar. The absence of Bcl-2 did not cause a uniform delay in the developmental program of sensory neurons, because the time course of nerve growth factor receptor expression (both trkA and p75) was unaffected in the trigeminal neurons of bcl-2-/- embryos. These findings indicate that Bcl-2 expression is required for the normal progression of a particular early maturational change in embryonic sensory neurons.
Indexed as
Identifiers
9547242PMC6792656W1919375397What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.