ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Selective fasciculation and divergent pathfinding decisions of embryonic chick motor axons projecting to fast and slow muscle regions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Ets2 Is an Activity-Dependent Transcriptional Regulator of a Fast-Twitch Muscle Program.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Quantitative Image Analysis of Axonal Morphology in In Vivo Model.Methods and protocols · 2023Article
- Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.eLife · 2019Article
- Ordered arrangement of dendrites within aeLife · 2018Article
- Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation.The Journal of cell biology · 2015Article
- Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.Development (Cambridge, England) · 2010Article
- Muscle fiber type specific induction of slow myosin heavy chain 2 gene expression by electrical stimulation.Experimental cell research · 2010Article
- The ups and downs of gene regulation by electrical activity in skeletal muscles.Journal of muscle research and cell motility · 2009Review
- Gamma and alpha motor neurons distinguished by expression of transcription factor Err3.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Activity-dependent repression of muscle genes by NFAT.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Receptor tyrosine phosphatases guide vertebrate motor axons during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Polysialylated neural cell adhesion molecule is necessary for selective targeting of regenerating motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Neuromuscular activity blockade induced by muscimol and d-tubocurarine differentially affects the survival of embryonic chick motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Proper motor function requires the precise matching of motoneuron and muscle fiber properties. The lack of distinguishing markers for early motoneurons has made it difficult to determine whether this matching is established by selective innervation during development or later via motoneuron-muscle fiber interactions. To examine whether chick motoneurons selectively innervate regions of their target containing either fast or slow muscle fibers, we backlabeled neurons from each of these regions with lipophilic dyes. We found that motor axons projecting to fast and slow muscle regions sorted into separate but adjacent fascicles proximally in the limb, long before they reached the muscle. More distally, these fascicles made divergent pathfinding decisions to course directly to the appropriate muscle fiber region. In contrast, axons projecting to different areas of an all-fast muscle did not fasciculate separately and became more intermingled as they coursed through the limb. Selective fasciculation of fast- and slow-projecting motoneurons was similar both before and after motoneuron cell death, suggesting that motoneurons specifically recognized and fasciculated with axons growing to muscle regions containing the appropriate muscle fiber type. Taken together, these results strongly support the hypothesis that "fast" and "slow" motoneurons are molecularly distinct before target innervation and that they use these differences to selectively fasciculate, pathfind to, and branch within the correct muscle fiber region from the outset of neuromuscular development.
Indexed as
Identifiers
9547238PMC6792639W2146045984What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.