Evidence map›Paper›PMID 9546623›Full record

ArticleMolecular and cellular biochemistry1998

Human platelets contain a novel 47 kDa thiol-oxidase having affinity for genomic sterol-regulatory sequence.

D Kaul, M Kaur, V Dhawan

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

D KaulDepartment of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
M Kaur
V Dhawan
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study provides evidence to support that human platelets possess a 47 kDa dual functional molecule having thiol-oxidase activity as well as high affinity for the SRE sequence in the human genome. On the basis of these as well as earlier results, we propose that Receptor 'Ck' dependent regulation of this dual functional 47 kDa molecule may provide a mechanism for the maintenance of cellular cholesterol homeostasis. Further, this mechanism may also explain the molecular basis of cholesterol-feedback lesion observed under premalignant conditions.

Indexed as

CCAAT-Enhancer-Binding ProteinsBlood PlateletsDNA-Binding ProteinsHumansIn Vitro TechniquesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMolecular WeightNuclear ProteinsOxidoreductasesOxidoreductases Acting on Sulfur Group DonorsSterol Regulatory Element Binding Protein 1Transcription FactorsCCAAT-Enhancer-Binding ProteinsDNA-Binding ProteinsNuclear ProteinsOxidoreductasesOxidoreductases Acting on Sulfur Group DonorsSREBF1 protein, humanSterol Regulatory Element Binding Protein 1thiol oxidase, 47 kDaTranscription Factors

Identifiers

PMID9546623
OpenAlexW274470745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.