ReviewBrain pathology (Zurich, Switzerland)1998
Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome?
Review in Brain pathology (Zurich, Switzerland), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 117 citations in OpenAlex.
- The extent of alpha-synuclein aggregate accumulation in neurons varies depending on the type of neurotransmitter they release.Scientific reports · 2025Article
- Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2024Review
- α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox.Cell & bioscience · 2021Review
- Dementia with Lewy bodies - from scientific knowledge to clinical insights.Nature reviews. Neurology · 2019Review
- Lewy Body Disease: Clinical and Pathological "Overlap Syndrome" Between Synucleinopathies (Parkinson Disease) and Tauopathies (Alzheimer Disease).Current neurology and neuroscience reports · 2018Review
- The neuropsychological profile of Alzheimer disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Staging neurodegenerative disorders: structural, regional, biomarker, and functional progressions.Neurotoxicity research · 2011Review
- Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance.Acta neuropathologica · 2008Article
- Mills syndrome with dementia: broadening the phenotype of FTD/MND.Journal of neurology · 2005Article
- Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene.Neurogenetics · 2004Article
- Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions.Brain pathology (Zurich, Switzerland) · 2004Article
- Dementia with Lewy bodies: disease concept and genetics.Neurogenetics · 2003Review
- Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.Brain pathology (Zurich, Switzerland) · 2003Article
- Neuropathology in mice expressing human alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.Brain pathology (Zurich, Switzerland) · 2000Article
- Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.The American journal of pathology · 1999Article
- alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome?Brain pathology (Zurich, Switzerland) · 1998Review
- Establishing a pathological diagnosis in degenerative dementias.Brain pathology (Zurich, Switzerland) · 1998Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lewy body formation is central to the pathological phenotype of a spectrum of disorders. The most familiar of these is the extrapyramidal syndrome of idiopathic Lewy-body Parkinson's disease (PD). Studies of dementia in the elderly suggest that another manifestation of Lewy body pathology is equally or more common than Parkinson's disease. This syndrome of Dementia with Lewy bodies (DLB) has been given a number of diagnostic labels and is characterised by dementia, relatively mild parkinsonism, visual hallucinations, and fluctuations in conscious level. Although many of these features can arise in Parkinson's disease, the patients with DLB tend to have early neuropsychiatric features which predominate the clinical picture, and the diagnosis of the syndrome in practice is more concerned with the differential diagnosis of Alzheimer's disease (AD). Distinction from AD has clinical importance because of potentially differing therapeutic implications. Diagnostic guidelines for the clinical diagnosis and pathological evaluation of DLB are reviewed. Research into the disorder has centered around characterising the clinical, neuropsychological, pathological, neurochemical and genetic relationships with Alzheimer's disease on the one hand, and Parkinson's disease on the other. Many cases of DLB have prominent pathological features of AD and there are some shared genetic risk factors. Differences from the pathology of PD are predominantly quantitative rather than qualitative and evidence is discussed which suggests that DLB represents a clinicopathological syndrome within the spectrum of Lewy body disorders. The possibility that the syndrome represents a chance association of PD and AD is not supported by published studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.