ArticleThe EMBO journal1998
Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression.International journal of molecular sciences · 2022Review
- Foxd4l1.1 negatively regulates transcription of neural repressor ventx1.1 during neuroectoderm formation in Xenopus embryos.Scientific reports · 2020Article
- Mandarin fish (Sinipercidae) genomes provide insights into innate predatory feeding.Communications biology · 2020Article
- A gene regulatory program controlling early Xenopus mesendoderm formation: Network conservation and motifs.Seminars in cell & developmental biology · 2017Review
- The identification of hematopoietic-specific regulatory elements forMolecular therapy. Methods & clinical development · 2016Review
- The role of heterodimeric AP-1 protein comprised of JunD and c-Fos proteins in hematopoiesis.The Journal of biological chemistry · 2012Article
- Ventx factors function as Nanog-like guardians of developmental potential in Xenopus.PloS one · 2012Article
- Article
- A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.Developmental biology · 2011Article
- Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning.PloS one · 2011Article
- Neural induction and factors that stabilize a neural fate.Birth defects research. Part C, Embryo today : reviews · 2009Review
- Sox3 expression is maintained by FGF signaling and restricted to the neural plate by Vent proteins in the Xenopus embryo.Developmental biology · 2008Article
- Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development.Mechanisms of development · 2007Article
- The Spemann organizer and embryonic head induction.The EMBO journal · 2001Review
- Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectopic expression of the ventralizing morphogen BMP-4 (bone morphogenetic protein-4) in the dorsal lip (Spemann organizer) of Xenopus embryos blocks transcription of dorsal-lip-specific early response genes. We investigated the molecular mechanism underlying the BMP-4-induced inhibition of the fork head gene XFD-1'. The promoter of this gene contains a BMP-triggered inhibitory element (BIE) which prevents activation of this gene at the ventral/vegetal side of the embryo in vivo. In the present study, we show that BMP-4-induced inhibition is not direct but indirect, and is mediated by Xvent homeobox proteins. Micro-injections of Xvent-1 RNA and XFD-1' promoter deletion mutants demonstrate that Xvent-1 mimics the effect of BMP-4 signalling not only by suppression of the XFD-1' gene, but also by utilizing the BIE. Suppression could be reverted using a dominant-negative Xvent-1 mutant. The repressor domain was localized to the N-terminal region of the protein. Gel-shift and footprint analyses prove that Xvent-1 binds to the BIE. Moreover, PCR-based target-site selection for the Xvent-1 homeodomain confirms distinct motifs within the BIE as preferential binding sites. Thus, biological and molecular data suggest that Xvent-1 acts as direct repressor for XFD-1' transcription and mediates BMP-4-induced inhibition.
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