ArticleBiophysical journal1998
Mathematical modeling and fluorescence imaging to study the Ca2+ turnover in skinned muscle fibers.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Caffeine as a tool to investigate sarcoplasmic reticulum and intracellular calcium dynamics in human skeletal muscles.Journal of muscle research and cell motility · 2021Review
- Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans.The Journal of physiology · 2021Article
- Exciting perspectives for Translational Myology in the Abstracts of the 2018Spring PaduaMuscleDays: Giovanni Salviati Memorial - Chapter III - Abstracts of March 16, 2018.European journal of translational myology · 2018Article
- Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.American journal of physiology. Cell physiology · 2015Article
- Studies of chi(2)/chi(3) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy.Biophysical journal · 2004Article
- Nandrolone decanoate treatment affects sarcoplasmic reticulum Ca(2+) ATPase function in skinned rat slow- and fast-twitch fibres.Pflugers Archiv : European journal of physiology · 2003Article
- Spark- and ember-like elementary Ca2+ release events in skinned fibres of adult mammalian skeletal muscle.The Journal of physiology · 2001Article
- Numerical analysis of Ca2+ depletion in the transverse tubular system of mammalian muscle.Biophysical journal · 2001Article
- Quantification of total calcium in terminal cisternae of skinned muscle fibers by imaging electron energy-loss spectroscopy.Journal of muscle research and cell motility · 1999Article
- Calcium release flux underlying Ca2+ sparks of frog skeletal muscle.The Journal of general physiology · 1999Article
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Authors and funding
3 authors.
Funding
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Abstract
A mathematical model was developed for the simulation of the spatial and temporal time course of Ca2+ ion movement in caffeine-induced calcium transients of chemically skinned muscle fiber preparations. Our model assumes cylindrical symmetry and quantifies the radial profile of Ca2+ ion concentration by solving the diffusion equations for Ca2+ ions and various mobile buffers, and the rate equations for Ca2+ buffering (mobile and immobile buffers) and for the release and reuptake of Ca2+ ions by the sarcoplasmic reticulum (SR), with a finite-difference algorithm. The results of the model are compared with caffeine-induced spatial Ca2+ transients obtained from saponin skinned murine fast-twitch fibers by fluorescence photometry and imaging measurements using the ratiometric dye Fura-2. The combination of mathematical modeling and digital image analysis provides a tool for the quantitative description of the total Ca2+ turnover and the different contributions of all interacting processes to the overall Ca2+ transient in skinned muscle fibers. It should thereby strongly improve the usage of skinned fibers as quantitative assay systems for many parameters of the SR and the contractile apparatus helping also to bridge the gap to the intact muscle fiber.
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