ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1998
Chromosome stability is maintained by short intercentromeric distance in functionally dicentric human Robertsonian translocations.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 52 citations in OpenAlex.
- Clinical and molecular cytogenetic findings and pregnancy outcomes of fetuses with isochromosome Y.Molecular cytogenetics · 2022Article
- Prevalence and Phenotypic Impact of Robertsonian Translocations.Molecular syndromology · 2021Review
- The Evolution of Chromosome Numbers: Mechanistic Models and Experimental Approaches.Genome biology and evolution · 2021Article
- The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA.Nature communications · 2018Review
- Centromere Destiny in Dicentric Chromosomes: New Insights from the Evolution of Human Chromosome 2 Ancestral Centromeric Region.Molecular biology and evolution · 2017Article
- Centromere inactivation on a neo-Y fusion chromosome in threespine stickleback fish.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Dicentric chromosomes: unique models to study centromere function and inactivation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy.Genetics research international · 2011Article
- Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.PLoS genetics · 2010Article
- Centromere activity in dicentric small supernumerary marker chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Article
- Genomic architecture and inheritance of human ribosomal RNA gene clusters.Genome research · 2008Article
- Engineered human dicentric chromosomes show centromere plasticity.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Article
- Centric fission--simple and complex mechanisms.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- The activation of a neocentromere in Drosophila requires proximity to an endogenous centromere.Genetics · 2001Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
While the formation of a dicentric chromosome often leads to chromosome instability, human dicentric Robertsonian translocations usually remain stable. To investigate the basis for this stability, we have examined the centromeres of 15 structurally dicentric rob(13q14q) Robertsonian translocations using immunofluorescence and fluorescence in situ hybridization (FISH). The immunofluorescence detection of centromere protein C (CENP-C) was used as a marker for centromere function as CENP-C seems to play an essential role in kinetochore structure and stability and was previously shown to be absent from inactive centromeres. In all 15 translocation-containing cell lines, CENP-C was confined to only one of the centromeres of the translocation in a fraction of the cells analyzed. This suggests that centromere inactivation commonly occurs on dicentric Robertsonian translocations and may serve as one mechanism allowing for their stability. However, in the majority of the translocations (12 out of 15), a portion of the cells analyzed displayed CENP-C immunofluorescence at both centromeres, suggesting that both centromeres were active and that the translocation was functionally dicentric. The percentage of cells with CENP-C at both centromeres ranged from 2% to 82%. These results support the hypothesis that the close proximity of two functional centromeres on Robertsonian translocations allows them to remain stable.
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