ArticleThe Journal of clinical investigation1998
The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer.International journal of molecular and cellular medicine · 2022Article
- Article
- Gene expression profiling informs HPV cervical histopathology but not recurrence/relapse after LEEP in ART-suppressed HIV+HPV+ women.Carcinogenesis · 2019Article
- The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.EMBO molecular medicine · 2013Article
- Unbiased proteomic analysis of proteins interacting with the HIV-1 5'LTR sequence: role of the transcription factor Meis.Nucleic acids research · 2012Article
- Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells.Journal of cancer research and clinical oncology · 2011Article
- The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds.Obstetrics and gynecology international · 2009Article
- Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.Nucleic acids research · 2008Article
- Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.Oncogene · 2006Article
- Brn-3a neuronal transcription factor functional expression in human prostate cancer.Prostate cancer and prostatic diseases · 2006Article
- The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo.Oncogene · 2001Article
- The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells.Oncogene · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cervical cellular transcription factors Brn-3a and Brn-3b have antagonistic effects on transcription of the human papilloma virus types 16 and 18 E6 and E7 oncogenes, with Brn-3a activating expression and Brn-3b repressing it. We therefore measured expression of Brn-3a and Brn-3b mRNAs in biopsies from 16 women with no detectable cervical abnormality, and in 14 women with cervical intraepithelial neoplasia grade 3 (CIN3) lesions. Although the mean level of Brn-3b expression was similar in both groups, the mean level of Brn-3a expression was over 300-fold higher in the CIN3 samples when compared with normals. Elevated expression of Brn-3a was also detected in 16 histologically normal regions of the cervix adjacent to the CIN3 lesions, indicating that elevation of Brn-3a levels is not confined to the lesion in women with CIN3, and is thus not a consequence of the oncogenic process. The elevated levels of Brn-3a in the CIN3 patient samples, together with the activating effect of Brn-3a on HPV-16 and -18 oncogene expression, suggest that induction of this factor is involved in activating HPV-16 and -18 oncogene expression in the cervix, and hence in the production of cervical cancers induced by HPV.
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