ArticleThe Journal of clinical investigation1998
Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization.Circulation · 2022Pooled it
- The inflammatory proteome, obesity, and medical weight loss and regain in humans.Obesity (Silver Spring, Md.) · 2023Trial
- Macrophages: friend or foe in diabetes pathogenesis and therapy.Frontiers in immunology · 2025Review
- The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch.Immunological reviews · 2024Review
- Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity.International journal of obesity (2005) · 2024Observational
- Circulating cancer-associated macrophage-like cells and macrophage-related cytokines in obese patients with advanced breast cancer who undergo neoadjuvant chemotherapy.Journal of Cancer · 2024Article
- Inflammatory bowel disease-associated intestinal fibrosis.Journal of pathology and translational medicine · 2023Review
- Effects ofAnimals : an open access journal from MDPI · 2022Article
- Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report.Medicina (Kaunas, Lithuania) · 2022Article
- Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism.Scientific reports · 2020Article
- Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia.Journal of clinical medicine · 2019Article
- Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression.International journal of medical sciences · 2019Article
- Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.Scientific reports · 2018Article
- Hematopoietic Stem Cell-derived Adipocytes Promote Tumor Growth and Cancer Cell Migration.International journal of cancer research and molecular mechanisms · 2017Article
- Measurement of body composition in response to a short period of overfeeding.Journal of physiological anthropology · 2014Article
- Adipose tissue plasticity from WAT to BAT and in between.Biochimica et biophysica acta · 2014Review
- Bacterial translocation - impact on the adipocyte compartment.Frontiers in immunology · 2014Review
- Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Effects of tocotrienol on tumor necrosis factor-α/d-galactosamine-induced steatohepatitis in rats.Journal of clinical biochemistry and nutrition · 2013Article
- Phosphatidylcholine induces apoptosis of 3T3-L1 adipocytes.Journal of biomedical science · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Adipose tissue growth results from de novo adipocyte recruitment (hyperplasia) and increased size of preexisting adipocytes. Adipocyte hyperplasia accounts for the severalfold increase in adipose tissue mass that occurs throughout life, yet the mechanism of adipocyte hyperplasia is unknown. We studied the potential of macrophage colony-stimulating factor (MCSF) to mediate adipocyte hyperplasia because of the profound effects MCSF exerts on pluripotent cell recruitment and differentiation in other tissues. We found that MCSF mRNA and protein were expressed by human adipocytes and that adipocyte MCSF expression was upregulated in rapidly growing adipose tissue that encircled acutely inflamed bowel and in adipose tissue from humans gaining weight (4-7 kg) with overfeeding. Localized overexpression of adipocyte MCSF was then induced in rabbit subcutaneous adipose tissue in vivo using adenoviral-mediated gene transfer. Successful overexpression of MCSF was associated with 16-fold increases in adipose tissue growth compared with a control adenovirus expressing beta-galactosidase. This occurred in the absence of increased cell size and in the presence of increased nuclear staining for MIB-1, a marker of proliferation. We conclude that MCSF participates in adipocyte hyperplasia and the physiological regulation of adipose tissue growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.