ArticleThe Journal of clinical investigation1998
Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imaging.Radiology · 2011 · on this mapTrial
- Atherosclerosis increases adventitial pressure and limits solute transport via fluid-balance mechanisms.Biomechanics and modeling in mechanobiology · 2025Article
- Monocyte Count as a Predictor of Major Adverse Limb Events in Aortoiliac Revascularization.Journal of clinical medicine · 2024Article
- A novel rabbit model of atherosclerotic vulnerable plaque established by cryofluid-induced endothelial injury.Scientific reports · 2024Article
- Giant cell arteritis: reviewing the advancing diagnostics and management.Eye (London, England) · 2023Review
- Healing the Ischaemic Heart: A Critical Review of Stem Cell Therapies.Reviews in cardiovascular medicine · 2023Review
- Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia.International journal of molecular sciences · 2022Article
- On vasa vasorum: A history of advances in understanding the vessels of vessels.Science advances · 2022Review
- Upregulation of Neogenin-1 by a CREB1-BAF47 Complex in Vascular Endothelial Cells is Implicated in Atherogenesis.Frontiers in cell and developmental biology · 2022Article
- Mechanically Rotating Intravascular Ultrasound (IVUS) Transducer: A Review.Sensors (Basel, Switzerland) · 2021Review
- Microdistribution of Magnetic Resonance Imaging Contrast Agents in Atherosclerotic Plaques Determined by LA-ICP-MS and SR-μXRF Imaging.Molecular imaging and biology · 2021Article
- Review
- Major gaps in human evidence for structure and function of the vasa vasora limit our understanding of the link with atherosclerosis.Journal of anatomy · 2021Review
- Carotid Extra-Media Thickness in Children: Relationships With Cardiometabolic Risk Factors and Endothelial Function.Frontiers in endocrinology · 2020Article
- The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis.Mediators of inflammation · 2019Review
- Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study.Journal of stroke · 2018Article
- Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support.Circulation. Heart failure · 2018Article
- Vasa Vasorum Angiogenesis: Key Player in the Initiation and Progression of Atherosclerosis and Potential Target for the Treatment of Cardiovascular Disease.Frontiers in immunology · 2018Review
- Semaphorin 7A Promotes VEGFA/VEGFR2-Mediated Angiogenesis and Intraplaque Neovascularization inFrontiers in physiology · 2018Article
- Porcine arteriogenesis based on vasa vasorum in a novel semi-acute occlusion model using high-resolution imaging.Heart and vessels · 2017Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Coronary arteries contain a network of vasa vasorum in the adventitia. The three-dimensional anatomy of the vasa vasorum in early coronary atherosclerosis is unknown. This study was designed to visualize and quantitate the three-dimensional spatial pattern of vasa vasorum in normal and experimental hypercholesterolemic porcine coronary arteries, using a novel computed tomography technique. Animals were killed after being fed either a high cholesterol diet (n = 4) or a control diet (n = 4) for 12 wk. The proximal left anterior descending coronary artery was removed from the heart, scanned, and reconstructed, and quantitation of vasa vasorum density was performed. Two different types of vasa vasorum were defined: first-order vasa vasorum ran longitudinally parallel to the vessel and second-order originated from first-order vasa circumferentially around the vessel wall. Compared with controls in hypercholesterolemic coronary arteries, there was a significant increase in the area of the vessel wall (3.86+/-0.22 vs. 8.07+/-0.45 mm2, respectively, P < 0.01) and in the density of vasa vasorum (1. 84+/-0.05/mm2 vs. 4.73+/-0.24/mm2; respectively, P = 0.0001). This occurred especially by an increase of second-order vasa vasorum and disorientation of normal vasa vasorum spatial pattern. This study suggests that adventitial neovascularization of vasa vasorum occurs in experimental hypercholesterolemic coronary arteries and may be a part of the early atherosclerotic remodeling process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.