ReviewJournal of medical genetics1998
Recurrence risks in mental retardation.
Review in Journal of medical genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- The recurrence risk of genetic complex diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- Positron emission tomography-computer tomography scan used as a monitoring tool following cellular therapy in cerebral palsy and mental retardation-a case report.Case reports in neurological medicine · 2013Article
- Unlocking Mendelian disease using exome sequencing.Genome biology · 2011Review
- Chromosome abnormality rate among Iranian patients with idiopathic mental retardation from consanguineous marriages.Archives of medical science : AMS · 2011Article
- Value for money? Array genomic hybridization for diagnostic testing for genetic causes of intellectual disability.American journal of human genetics · 2010Article
- Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues.Journal of autism and developmental disorders · 2007Article
- X linked mental retardation: a clinical guide.Journal of medical genetics · 2006Review
- Screening of ARX in mental retardation families: Consequences for the strategy of molecular diagnosis.Neurogenetics · 2006Article
- Subtelomeric study of 132 patients with mental retardation reveals 9 chromosomal anomalies and contributes to the delineation of submicroscopic deletions of 1pter, 2qter, 4pter, 5qter and 9qter.BMC medical genetics · 2005Article
- Sexual abuse prevention for individuals with mental retardation: considerations for genetic counselors.Journal of genetic counseling · 2004Article
- Conducting genetic epidemiology studies of autism spectrum disorders: issues in matching.Journal of autism and developmental disorders · 2004Review
- A rational approach to the child with mental retardation for the paediatrician.Paediatrics & child health · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite improvements in diagnostic techniques and progress made in mapping genes associated with syndromal mental handicap, the estimation of recurrence risks in non-syndromal mental retardation is still dependent on empirical data. Unfortunately, few studies are available to guide the clinician and their results differ significantly. For example, recurrence risks to all sibs of a male index patient with severe mental retardation vary between 3.5% and 14% in commonly quoted series. The present review highlights the problems involved in interpreting the previous work in this area and discusses the definition of mental retardation according to the degree of severity, phenotype, and its pattern of inheritance. In planning future studies, an appreciation of these issues should allow us to derive accurate and comparable risk figures for use in counselling affected subjects and their families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.