ArticleJournal of neuro-oncology1998
Expression of annexin II in glioma cell lines and in brain tumor biopsies.
Article in Journal of neuro-oncology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Aberrant proteins expressed in skin fibroblasts of Parkinson's disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes.Biomedical reports · 2021Article
- Annexin A2 in Inflammation and Host Defense.Cells · 2020Review
- Stomatin-like protein 2 regulates survivin expression in non-small cell lung cancer cells through β-catenin signaling pathway.Cell death & disease · 2018Article
- Article
- Annexin A2 system in human biology: cell surface and beyond.Seminars in thrombosis and hemostasis · 2013Review
- Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms.The Journal of biological chemistry · 2012Article
- The annexin A2/S100A10 system in health and disease: emerging paradigms.Journal of biomedicine & biotechnology · 2012Review
- Annexin A2 promotes glioma cell invasion and tumor progression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The role of annexin A2 in tumorigenesis and cancer progression.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
- Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects.The Journal of biological chemistry · 2010Article
- tPA receptors and the fibrinolytic response in multiple sclerosis lesions.The American journal of pathology · 2005Article
- Expression of annexin II in conventional renal cell carcinoma is correlated with Fuhrman grade and clinical outcome.Virchows Archiv : an international journal of pathology · 2004Article
- Nuclear annexin II negatively regulates growth of LNCaP cells and substitution of ser 11 and 25 to glu prevents nucleo-cytoplasmic shuttling of annexin II.BMC biochemistry · 2003Article
- Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Annexin II is a calcium and phospholipid binding protein and a substrate for protein-tyrosine kinases. Increased levels of annexin II are observed in various cancer cells and tissues, and the molecule has been proposed as a marker of malignancy in vivo. Annexin II was expressed in four glioma cell lines (D-54MG, D-37MG, U251MG and GaMG), as determined by Western blot analyses, immunofluorescence staining and flow cytometric measurements. In addition, annexin II expression was also found in cryostat sections obtained from 15 consecutive brain tumor biopsies: Ten were histologically classified as glioblastomas, one as an astrocytoma, two as meningiomas and two as brain metastases. Cultured spheroids from the glioma cell lines and from three of the glioblastoma biopsies showed lower levels of annexin II, than found in the monolayers of the cell lines and in the freshly cut biopsies. The annexin II expression of the cell lines were not found to be related to their proliferative, migratory or invasive properties. These findings indicate that although annexin II may serve as a marker of malignancy in vivo, its expression can be reduced in vitro, and appear unrelated to malignant features of glioma cell lines.
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