ArticleDiabetes care1998
Biological variation of glycated hemoglobin. Implications for diabetes screening and monitoring.
Article in Diabetes care, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- Continuous subcutaneous insulin infusion versus multiple daily injections of insulin for pregnant women with diabetes.The Cochrane database of systematic reviews · 2016Pooled it
- Hemoglobin glycation index, calculated from a single fasting glucose value, as a prediction tool for severe hypoglycemia and major adverse cardiovascular events in DEVOTE.BMJ open diabetes research & care · 2021Trial
- The hemoglobin glycation index identifies subpopulations with harms or benefits from intensive treatment in the ACCORD trial.Diabetes care · 2015Trial
- Do high blood glucose peaks contribute to higher HbA1c? Results from repeated continuous glucose measurements in children.World journal of pediatrics : WJP · 2008Trial
- First-line antihypertensive treatment in patients with pre-diabetes: rationale, design and baseline results of the ADaPT investigation.Cardiovascular diabetology · 2008Trial
- The Diabetes Prevention Program: baseline characteristics of the randomized cohort. The Diabetes Prevention Program Research Group.Diabetes care · 2000Trial
- Discussion on the calculation formula of haemoglobin glycation index for Chinese population.Scientific reports · 2024Article
- Microfluidic-based systems for the management of diabetes.Drug delivery and translational research · 2024Review
- Associations Between HbA1c and Glucose Time in Range Using Continuous Glucose Monitoring in Type 1 Diabetes: Cross-Sectional Population-Based Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Significantly hypoglycemic effect of a novel functional bread rich in mulberry bark and improving the related functions of liver, pancreas, and kidney, on T2D mice.Food science & nutrition · 2021Article
- Preventing misdiagnosis of diabetes in the elderly: age-dependent HbA1c reference intervals derived from two population-based study cohorts.BMC endocrine disorders · 2019Article
- Hypertriglyceridemia and Its Association with HbA1c Test: A ProspectiveInternational journal of endocrinology · 2019Article
- Translating the HbA1c assay into estimated average glucose values in children and adolescents with type 1 diabetes mellitus.Acta bio-medica : Atenei Parmensis · 2018Article
- Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.Experimental neurology · 2017Article
- Enhancing Glycemic Control via Detection of Insulin Using Electrochemical Impedance Spectroscopy.Journal of diabetes science and technology · 2017Article
- Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals.PloS one · 2017Article
- Serum fructosamine a better indicator than glycated hemoglobin for monitoring gestational diabetes mellitus.Journal of pharmacy & bioallied sciences · 2015Article
- Article
- Glucoregulatory function among African Americans and European Americans with normal or pre-diabetic hemoglobin A1c levels.Metabolism: clinical and experimental · 2014Article
- HbA1c for screening and diagnosis of diabetes mellitus.Endocrine · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the inherent potential of glycated hemoglobin as a screening test for type 2 diabetes by determining the biological variation in nondiabetic subjects. RESEARCH DESIGN AND
methodsHbA1c values were measured by high-performance liquid chromatography (HPLC) in 12 nondiabetic subjects (7 men and 5 women; median age, 40 years [range, 21-55 years]) on 10 fortnightly occasions. The nondiabetic index of individuality (IOI) for HbA1c (i.e., the square root of the ratio of intra- to interindividual variance) was determined. Any test with an IOI of 1.4 has the most potential in disease screening, while one of 0.6 will be of little value.
resultsThe analytical variance contributed to 9% of the total test variance, intraindividual variance, 6%; and interindividual variance, 85%. The IOI was, therefore, only 0.27. Thus, nondiabetic HbA1c values vary markedly between subjects, while values in the same individual change little with time. As such, to lie outside the assay reference range, the HbA1c values of some nondiabetic subjects must exceed 12 SD from their usual mean value, while in others a change of only 2 SD would be sufficient.
conclusionsThis fundamental characteristic of HbA1c means that even if analytical methods improve, glycated hemoglobin measurements will always be of limited value when screening for type 2 diabetes. If similar interindividual differences also exist in diabetic subjects, then patients with the same glycemic control may vary by at least 1-2%, which has implications in setting glycated hemoglobin targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.