ArticleProceedings of the National Academy of Sciences of the United States of America1998
Src interacts with dynamin and synapsin in neuronal cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 93 citations in OpenAlex.
- Mindin-mediated αM-integrin endocytosis activates STAT3 to maintain keratinocyte stemness.Cell communication and signaling : CCS · 2026Article
- Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease.Frontiers in cellular neuroscience · 2021Article
- Lung Endothelial Transcytosis.Comprehensive Physiology · 2020Review
- SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma.Oncotarget · 2016Article
- The N2-Src neuronal splice variant of C-Src has altered SH3 domain ligand specificity and a higher constitutive activity than N1-Src.FEBS letters · 2015Article
- Lipid rafts in neurodegeneration and neuroprotection.Molecular neurobiology · 2014Review
- Osteoblast differentiation and migration are regulated by dynamin GTPase activity.The international journal of biochemistry & cell biology · 2014Article
- Regulation of SRC family kinases in human cancers.Journal of signal transduction · 2011Article
- HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.Molecular vision · 2010Article
- SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin.Molecular and cellular biology · 2010Article
- Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts.Molecular and cellular biology · 2009Article
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- c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling.Cellular signalling · 2008Article
- Article
- CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling.Biochemical Society transactions · 2005Review
- Colocalization of synapsin and actin during synaptic vesicle recycling.The Journal of cell biology · 2003Article
- Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis.Molecular and cellular biology · 2003Article
- Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1.The Journal of biological chemistry · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The nonreceptor tyrosine kinase Src is expressed at a high level in cells that are specialized for regulated secretion, such as the neuron, and is concentrated on secretory vesicles or at the site of exocytosis. To investigate the possibility that Src may play a role in regulating membrane traffic, we searched for neuronal proteins that will interact with Src. The SH3 domain of Src, but not that of the splice variant N-Src, bound to three proteins from mouse synaptosomes or PC12 cells: dynamin, synapsin Ia, and synapsin Ib. Dynamin and the synapsins coprecipitated with Src from PC12 cell extracts, and they colocalized with a subset of Src in the PC12 cell by immunofluorescence. Neither dynamin nor the synapsins were phosphorylated by Src, suggesting that the interaction of these proteins serves to direct the kinase activity of Src toward other proteins in the vesicle population. In immunoprecipitates containing Src and dynamin, the clathrin adaptor protein alpha-adaptin was also found. The association of Src and synapsin suggests a role for Src in the life cycle of the synaptic vesicle. The identification of a complex containing Src, dynamin, and alpha-adaptin indicates that Src may play a more general role in membrane traffic as well.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.