ArticleProceedings of the National Academy of Sciences of the United States of America1998
Genetic analysis using genomic representations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- Article
- Development of High-Density SNP Markers and Their Application in Evaluating Genetic Diversity and Population Structure inFrontiers in plant science · 2019Article
- High-density genetic map construction and identification of a locus controlling weeping trait in an ornamental woody plant (Prunus mume Sieb. et Zucc).DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- An SNP-based saturated genetic map and QTL analysis of fruit-related traits in cucumber using specific-length amplified fragment (SLAF) sequencing.BMC genomics · 2014Article
- An efficient method for high-fidelity messenger RNA amplification from a small amount of total RNA.Biomedical reports · 2013Article
- SLAF-seq: an efficient method of large-scale de novo SNP discovery and genotyping using high-throughput sequencing.PloS one · 2013Article
- Comparison of whole genome amplification methods for analysis of DNA extracted from microdissected early breast lesions in formalin-fixed paraffin-embedded tissue.ISRN oncology · 2012Article
- Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer.PloS one · 2011Article
- High-throughput identification of genetic markers using representational oligonucleotide microarray analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification.Cancer biology & therapy · 2008Article
- Comparing whole genomes using DNA microarrays.Nature reviews. Genetics · 2008Review
- Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.The American journal of pathology · 2006Article
- Whole genome amplification of plasma-circulating DNA enables expanded screening for allelic imbalance in plasma.The Journal of molecular diagnostics : JMD · 2006Article
- Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors.The Journal of molecular diagnostics : JMD · 2005Article
- A versatile statistical analysis algorithm to detect genome copy number variation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- DNA amplification method tolerant to sample degradation.Genome research · 2004Article
- Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples.Nucleic acids research · 2004Article
- Whole genome DNA copy number changes identified by high density oligonucleotide arrays.Human genomics · 2004Article
- High-resolution analysis of DNA copy number using oligonucleotide microarrays.Genome research · 2004Article
- Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays.BMC genomics · 2004Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Analysis of the genetic changes in human tumors is often problematical because of the presence of normal stroma and the limited availability of pure tumor DNA. However, large amounts of highly reproducible "representations" of tumor and normal genomes can be made by PCR from nanogram amounts of restriction endonuclease cleaved DNA that has been ligated to oligonucleotide adaptors. We show here that representations are useful for many types of genetic analyses, including measuring relative gene copy number, loss of heterozygosity, and comparative genomic hybridization. Representations may be prepared even from sorted nuclei from fixed and archived tumor biopsies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.