ArticleGenetics1998
Selection with recurrent backcrossing to develop congenic lines for quantitative trait loci analysis.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- A large and diverse autosomal haplotype is associated with sex-linked colour polymorphism in the guppy.Nature communications · 2022Article
- The relation between the genetic architecture of quantitative traits and long-term genetic response.Journal of applied genetics · 2014Article
- TLR signaling controls lethal encephalitis in WNV-infected brain.Brain research · 2014Article
- Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus.Molecular ecology · 2012Article
- Association mapping in outbred populations: power and efficiency when genotyping parents and phenotyping progeny.Genetics · 2009Article
- QTL analysis reveals context-dependent loci for seed glucosinolate trait in the oilseed Brassica juncea: importance of recurrent selection backcross scheme for the identification of 'true' QTL.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2007Article
- Phenotypic selection for dormancy introduced a set of adaptive haplotypes from weedy into cultivated rice.Genetics · 2005Article
- Selection in backcross programmes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- High-resolution mapping of quantitative trait loci by selective recombinant genotyping.Genetics · 2003Article
- Precision and high-resolution mapping of quantitative trait loci by use of recurrent selection, backcross or intercross schemes.Genetics · 2002Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SEWALL WRIGHT suggested that genes of large effect on a quantitative trait could be isolated by recurrent backcrossing with selection on the trait. Loci [quantitative trait loci (QTL)] at which the recurrent and nonrecurrent lines have genes of different large effect on the trait would remain segregating, while other loci would become fixed for the gene carried by the recurrent parent. If the recurrent line is inbred and the backcrossing and selection is conducted in a series of replicate lines, in each of which only one backcross parent is selected for each generation, the lines will become congenic to the recurrent parent except for the QTL of large effect and closely linked regions of the genome, and these regions can be identified using a dense set of markers that differ between the parental lines. Such lines would be particularly valuable for subsequent fine-scale mapping and gene cloning; but by chance, even QTL of large effect will be lost from some lines. The probability that QTL of specified effect remain segregating is computed as a function of its effect on the trait, the intensity of selection, and the number of generations of backcrossing. Analytical formulas are given for one or two loci, and simulation is used for more. It is shown that the method could have substantial discriminating ability and thus potential practical value.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.