ArticleGenetics1998
The involvement of cellular recombination and repair genes in RNA-mediated recombination in Saccharomyces cerevisiae.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Brain cell somatic gene recombination and its phylogenetic foundations.The Journal of biological chemistry · 2020Review
- What Can Long Terminal Repeats Tell Us About the Age of LTR Retrotransposons, Gene Conversion and Ectopic Recombination?Frontiers in plant science · 2020Article
- Protein-Coding Genes' Retrocopies and Their Functions.Viruses · 2017Review
- Emergence and loss of spliceosomal twin introns.Fungal biology and biotechnology · 2017Article
- Spliceosomal intronogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Evolution of the Exon-Intron Structure in Ciliate Genomes.PloS one · 2016Article
- Recurrent loss of specific introns during angiosperm evolution.PLoS genetics · 2014Article
- Evolution of gene structural complexity: an alternative-splicing-based model accounts for intron-containing retrogenes.Plant physiology · 2014Article
- On the origin and evolution of plant brassinosteroid receptor kinases.Journal of molecular evolution · 2014Article
- Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes.Immunogenetics · 2012Article
- Diversity-generating retroelement homing regenerates target sequences for repeated rounds of codon rewriting and protein diversification.Molecular cell · 2008Article
- Retrosequence formation restructures the yeast genome.Genes & development · 2007Article
- Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number.Genome research · 2006Article
- The pattern of intron loss.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors.Molecular and cellular biology · 2004Article
- A phylogeny of caenorhabditis reveals frequent loss of introns during nematode evolution.Genome research · 2004Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously demonstrated that a reverse transcript of a cellular reporter gene (his3-AI) can serve as the donor for gene conversion of a chromosomal his3-deltaMscI target sequence, and that this process requires the yeast recombination gene RAD52. In this study, we examine the involvement of other recombination and repair genes in RNA-mediated recombination, and gain insight into the nature of the recombination intermediate. We find that mutation of the mitotic RecA homologs RAD51, RAD55, and RAD57 increases the rate of RNA-mediated recombination relative to the wild type, and that these gene functions are not required for RNA-mediated gene conversion. Interestingly, RAD1 is required for RNA-mediated gene conversion of chromosomal his3-deltaMscI sequences, suggesting that the cDNA intermediate has a region of nonhomology that must be removed during recombination with target sequences. The observation that both RAD1 and RAD52 are required for RNA-mediated gene conversion of chromosomal but not plasmid sequences indicates a clear difference between these two pathways of homologous RNA-mediated recombination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.