ArticleThe Histochemical journal1998
Immunohistochemical localization of angiotensin II in the mouse pancreas.
Article in The Histochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- ACE2 function in the pancreatic islet: Implications for relationship between SARS-CoV-2 and diabetes.Acta physiologica (Oxford, England) · 2021Review
- The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).Physiological reviews · 2018Review
- High-fat diet-induced glucose dysregulation is independent of changes in islet ACE2 in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Angiotensin converting enzyme 2: a new important player in the regulation of glycemia.IUBMB life · 2013Review
- Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice.American journal of physiology. Endocrinology and metabolism · 2013Article
- The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2012Review
- Distribution of a novel binding site for angiotensins II and III in mouse tissues.Regulatory peptides · 2010Article
- The sweeter side of ACE2: physiological evidence for a role in diabetes.Molecular and cellular endocrinology · 2009Review
- The physiology of a local renin-angiotensin system in the pancreas.The Journal of physiology · 2007Review
- Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans.Diabetologia · 2006Article
- Article
- Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets.Diabetologia · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have suggested the presence of a tissue renin-angiotensin II system in the pancreas. These studies were based on the observation of several key components of the renin-angiotensin II system using molecular biological, biochemical and pharmacological approaches. In the present study, angiotensin II was localized immunohistochemically in the mouse pancreas using an indirect immunoperoxidase-staining technique. The results showed that angiotensin II-like immunoreactivity was localized predominantly in the endothelial cells of pancreatic blood vessels and the epithelial cells of pancreatic ducts from a subgroup of the vessels and ducts. Compared with those found in the pancreatic blood vessels and ductal system, a less pronounced immunoreactivity for angiotensin II was also observed in the acinar cells and in the smooth muscle layers overlying the pancreatic ducts as well as the blood vessels. However, no angiotensin II-like immunoreactivity was detected in the islet cells. Taken together with previous findings, the present results suggest a local angiotensin II-forming system in the mouse pancreas, which may be a significant autocrine or paracrine modulator of diverse pancreatic functions, including regulation of pancreatic blood flow and pancreatic anion secretion.
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