ArticleJournal of bacteriology1998
The CIRCE element and its putative repressor control cell cycle expression of the Caulobacter crescentus groESL operon.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- A calcium-binding protein-sigV regulatory circuit modulates stress adaptation and persistence in Caulobacter vibrioides.Archives of microbiology · 2026Article
- A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress.bioRxiv : the preprint server for biology · 2025Article
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- The Protein Quality Control Network inFrontiers in molecular biosciences · 2021Review
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- Molecular Basis and Ecological Relevance ofmBio · 2019Article
- Growth-driven displacement of protein aggregates along the cell length ensures partitioning to both daughter cells in Caulobacter crescentus.Molecular microbiology · 2019Article
- Genomic insights into bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2010Review
- GroES/GroEL and DnaK/DnaJ have distinct roles in stress responses and during cell cycle progression in Caulobacter crescentus.Journal of bacteriology · 2006Article
- Global gene expression analysis of the heat shock response in the phytopathogen Xylella fastidiosa.Journal of bacteriology · 2006Article
- Characterization of the groEL and groES loci in Bifidobacterium breve UCC 2003: genetic, transcriptional, and phylogenetic analyses.Applied and environmental microbiology · 2004Article
- Functional and structural analysis of HrcA repressor protein from Caulobacter crescentus.Journal of bacteriology · 2004Article
- ClgR, a novel regulator of clp and lon expression in Streptomyces.Journal of bacteriology · 2004Article
- Isolation and characterization of NaCl-sensitive mutants of Caulobacter crescentus.Applied and environmental microbiology · 2003Article
- Conserved regulatory elements of the promoter sequence of the gene rpoH of enteric bacteria.Nucleic acids research · 2001Article
- Role of HrcA and CIRCE in the heat shock regulatory network of Bradyrhizobium japonicum.Journal of bacteriology · 2000Article
- Differential and independent roles of a sigma(32) homolog (RpoH) and an HrcA repressor in the heat shock response of Agrobacterium tumefaciens.Journal of bacteriology · 1999Article
- Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP protease.Journal of bacteriology · 1999Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The groESL operon is under complex regulation in Caulobacter crescentus. In addition to strong induction after exposure to heat shock, under physiological growth conditions, its expression is subject to cell cycle control. Transcription and translation of the groE genes occur primarily in predivisional cells, with very low levels of expression in stalked cells. The regulatory region of groESL contains both a sigma32-like promoter and a CIRCE element. Overexpression of C. crescentus sigma32 gives rise to higher levels of GroEL and increased levels of the groESL transcript coming from the sigma32-like promoter. Site-directed mutagenesis in CIRCE has indicated a negative role for this cis-acting element in the expression of groESL only at normal growth temperatures, with a minor effect on heat shock induction. Furthermore, groESL-lacZ transcription fusions carrying mutations in CIRCE are no longer cell cycle regulated. Analysis of an hrcA null strain, carrying a disruption in the gene encoding the putative repressor that binds to the CIRCE element, shows constitutive synthesis of GroEL throughout the Caulobacter cell cycle. These results indicate a negative role for the hrcA gene product and the CIRCE element in the temporal control of the groESL operon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.