Evidence map›Paper›PMID 9536942›Full record

ArticleGut1998

Bone mineral density and nutritional status in children with chronic inflammatory bowel disease.

A M Boot, J Bouquet, E P Krenning, S M de Muinck Keizer-Schrama

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Conceptual Model of Lean Body Mass in Pediatric Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2019
    Pooled it
  2. Skeletal health of children and adolescents with inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2011
    Guideline
  3. Trial
  4. Trial
  5. Trial
  6. Bone Health in Paediatric Inflammatory Bowel Disease.Diagnostics (Basel, Switzerland) · 2025
    Review
  7. Low bone mineral density is associated with fatty liver disease and respiratory illness in a pediatric mortality sample.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
  8. Article
  9. Observational
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Bone Health in Glomerular Kidney Disease.Current osteoporosis reports · 2019
    Review
  16. Article
  17. Article
  18. Observational
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A M BootDepartment of Paediatrics, Erasmus University, Rotterdam, The Netherlands.
J Bouquet
E P Krenning
S M de Muinck Keizer-Schrama

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoporosis has been reported in adult patients with inflammatory bowel disease.

aimsTo evaluate bone mineral density (BMD), nutritional status, and determinants of BMD in children with inflammatory bowel disease. PATIENTS: Fifty five patients (34 boys and 21 girls, age range 4-18) were studied; 22 had Crohn's disease and 33 ulcerative colitis.

methodsLumbar spine and total body BMD, and body composition were assessed by dual energy x ray absorptiometry (DXA). Results were expressed as standard deviation scores (SDS). Lean body mass was also assessed by bioelectrical impedance analysis (BIA). Yearly measurements during two years were performed in 21 patients.

resultsThe mean SDS of lumbar spine BMD and total body BMD were significantly lower than normal (-0.75 and -0.95, both p < 0.001). Height SDS and body mass index SDS were also decreased. The decrease in BMD SDS could not be explained by delay in bone maturation. The cumulative dose of prednisolone correlated negatively with lumbar spine BMD SDS (r = -0.32, p < 0.02). Body mass index SDS correlated positively with total body BMD SDS (r = 0.36, p < 0.02). Patients with Crohn's disease had significantly lower lumbar spine and total body BMD SDS than patients with ulcerative colitis, even after adjustment for cumulative dose of prednisolone. In the longitudinal data cumulative dose of prednisolone between the measurements correlated negatively with the change in lumbar spine and total body BMD SDS. Lean tissue mass measured by DXA had a strong correlation with lean body mass measured by BIA (r = 0.98).

conclusionsChildren with inflammatory bowel disease have a decreased BMD. Children with Crohn's disease have a higher risk of developing osteopaenia than children with ulcerative colitis. Corticosteroid therapy and nutritional status are important determinants of BMD in these patients.

Indexed as

Bone DensityNutritional StatusAbsorptiometry, PhotonAdolescentBody CompositionBody HeightBody Mass IndexChildChild, PreschoolColitis, UlcerativeCrohn DiseaseCross-Sectional StudiesElectric ImpedanceFemaleGlucocorticoidsHumansGlucocorticoidsPrednisolone

Identifiers

PMID9536942
PMCPMC1726993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.