ArticleGut1998
Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis.
Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: responders versus nonresponders.World journal of gastroenterology · 2006Trial
- Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer.Nature microbiology · 2025Article
- Inflammatory bowel disease and carcinogenesis.Cancer metastasis reviews · 2022Review
- Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats.Environmental science and pollution research international · 2022Article
- The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders.Nutrients · 2022Review
- Arginine-dependent immune responses.Cellular and molecular life sciences : CMLS · 2021Review
- Genetic Pathogenesis of Inflammation-Associated Cancers in Digestive Organs.Pathogens (Basel, Switzerland) · 2021Review
- Heparin-Coated Albumin Nanoparticles for Drug Combination in Targeting Inflamed Intestine.Advanced healthcare materials · 2020Article
- Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways.World journal of gastroenterology · 2020Review
- Time-Dependent Indirect Antioxidative Effects of Oat Beta-Glucans on Peripheral Blood Parameters in the Animal Model of Colon Inflammation.Antioxidants (Basel, Switzerland) · 2020Article
- PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2, 4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility.Inflammopharmacology · 2020Article
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- Can Nrf2 Modulate the Development of Intestinal Fibrosis and Cancer in Inflammatory Bowel Disease?International journal of molecular sciences · 2019Review
- Unique Regulation of Enterocyte Brush Border Membrane Na-Glutamine and Na-Alanine Co-Transport by Peroxynitrite during Chronic Intestinal Inflammation.International journal of molecular sciences · 2019Article
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- A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease.Bioinformatics (Oxford, England) · 2018Article
- The Anti-Inflammatory Effect and Structure of EPCP1-2 from Crypthecodinium cohnii via Modulation of TLR4-NF-κB Pathways in LPS-Induced RAW 264.7 Cells.Marine drugs · 2017Article
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- Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2016Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased production of reactive metabolites of oxygen and nitrogen has been implicated in chronic inflammation of the gut. The object of this study was to examine the magnitude and location of nitric oxide synthase (NOS) activity and peroxynitrite formation in the colonic mucosa of patients with ulcerative colitis in relation to the degree of inflammation. SUBJECTS: Thirty three patients with active ulcerative colitis (17 with mild or moderate inflammation, 16 with severe inflammation).
methodsInducible NOS activity was determined in the colonic mucosa by measuring the conversion of L-arginine to citrulline in the absence of calcium. The localisation of NOS and nitrotyrosine immunoreactivity was assessed immunohistochemically using the labelled streptavidin biotin method.
resultsInducible NOS activity increased in parallel with the degree of inflammation of the mucosa. Expression of inducible NOS was found not only in the lamina propria, but also in the surface of the epithelium. Peroxynitrite formation as assessed by nitrotyrosine staining was frequently observed in the lamina propria of actively inflamed mucosa.
conclusionsNitric oxide and peroxynitrite formation may play an important role in causing irreversible cellular injury to the colonic mucosa in patients with active ulcerative colitis.
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