ArticleJournal of muscle research and cell motility1998
Interaction of troponin-H and glutathione S-transferase-2 in the indirect flight muscles of Drosophila melanogaster.
Article in Journal of muscle research and cell motility, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Evolution of chemosensory and detoxification gene families across herbivorous Drosophilidae.G3 (Bethesda, Md.) · 2023Article
- Evolution of chemosensory and detoxification gene families across herbivorous Drosophilidae.bioRxiv : the preprint server for biology · 2023Article
- Article
- Investigating the molecular basis of multiple insecticide resistance in a major malaria vector Anopheles funestus (sensu stricto) from Akaka-Remo, Ogun State, Nigeria.Parasites & vectors · 2020Article
- Nanoscopy reveals the layered organization of the sarcomeric H-zone and I-band complexes.The Journal of cell biology · 2020Article
- Stretch activation properties of Drosophila and Lethocerus indirect flight muscle suggest similar calcium-dependent mechanisms.American journal of physiology. Cell physiology · 2017Article
- The earliest molecular response to stretch of insect flight muscle as revealed by fast X-ray diffraction recording.Scientific reports · 2017Article
- Genomic Features of the Damselfly Calopteryx splendens Representing a Sister Clade to Most Insect Orders.Genome biology and evolution · 2017Article
- The tymbal muscle of cicada has flight muscle-type sarcomeric architecture and protein expression.Zoological letters · 2017Article
- Structure, function and evolution of insect flight muscle.Biophysics (Nagoya-shi, Japan) · 2011Review
- Decreased detoxification genes and genome size make the human body louse an efficient model to study xenobiotic metabolism.Insect molecular biology · 2010Article
- Comparative analysis of crystallins and lipids from the lens of Antarctic toothfish and cow.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
- In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation.Journal of muscle research and cell motility · 2010Article
- Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle.Progress in neurobiology · 2008Review
- Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma.PloS one · 2007Article
- Transcription profiling of a recently colonised pyrethroid resistant Anopheles gambiae strain from Ghana.BMC genomics · 2007Article
- Tissue and life stage specificity of glutathione S-transferase expression in the Hessian fly, Mayetiola destructor: implications for resistance to host allelochemicals.Journal of insect science (Online) · 2007Article
- Passive stiffness in Drosophila indirect flight muscle reduced by disrupting paramyosin phosphorylation, but not by embryonic myosin S2 hinge substitution.Biophysical journal · 2006Article
- A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee.Insect molecular biology · 2006Article
- The Suppressor of Killer of prune, a unique glutathione S-transferase.Journal of bioenergetics and biomembranes · 2006Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila indirect flight muscles (IFMs) contain a 35 kDa protein which cross-reacts with antibodies to the IFM specific protein troponin-H isoform 34 (TnH-34). Peptide fingerprinting and peptide sequencing showed that this 35 kDa protein is glutathione S-transferase-2 (GST-2). GST-2 is present in the asynchronous indirect flight muscles but not in the synchronous tergal depressor of the trochanter (jump muscle). Genetic dissection of the sarcomere showed that GST-2 is stably associated with the thin filaments but the presence of myosin is required to achieve the correct stoichiometry, suggesting that there is also an interaction with the thick filament. The two Drosophila TnHs (isoforms 33 and 34) are naturally occurring fusion proteins in which a proline-rich extension of approximately 250 amino acids replaces the 27 C-terminal residues of the muscle-specific tropomyosin II isoform. The proteolytic enzyme, Igase, cleaves the hydrophobic C-terminal sequence of TnH-34 at three sites and TnH-33 at one site. This results in the release of GST-2 from the myofibril. The amount of GST-2 stably bound to the myofibril is directly proportional to the total amount of undigested TnH. It is concluded that GST-2 in the thin filament is stabilized there by interaction with TnH. We speculate that the hydrophobic N-terminal region of GST-2 interacts with the hydrophobic C-terminal extension of TnH, and that both are close to a myosin cross-bridge.
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