ArticleImmunology1998
The dual role of interferon-gamma in experimental Staphylococcus aureus septicaemia versus arthritis.
Article in Immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 91 citations in OpenAlex.
- Review
- Network Pharmacology and Molecular Docking: Exploring the Mechanism of Peppermint in Mastitis Prevention and Treatment in Dairy Cows.Veterinary sciences · 2025Article
- Stem cell activity shapes the pleiotropic effects of IFN-γ and TGF-β in autoimmune diseases, infections, and cancer, and drives autoimmune flares and remissions.Frontiers in immunology · 2025Review
- Clinical and microbiological characteristics of persistent Staphylococcus aureus bacteremia, risk factors for mortality, and the role of CD4Scientific reports · 2024Article
- Immunization with a peptide mimicking lipoteichoic acid induces memory B cells in BALB/c mice.BMC infectious diseases · 2024Article
- Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies.Frontiers in microbiology · 2024Review
- Superantigens promoteProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Bacteria and Host Interplay inPathogens (Basel, Switzerland) · 2021Review
- Targeting leukocidin-mediated immune evasion protects mice from Staphylococcus aureus bacteremia.The Journal of experimental medicine · 2020Article
- Probiotic Exopolysaccharide Protects against SystemicInfection and immunity · 2019Article
- Vaccine display on artificial bacterial spores enhances protective efficacy against Staphylococcus aureus infection.FEMS microbiology letters · 2018Article
- Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy.Nature communications · 2017Article
- IFN-γ targets macrophage-mediated immune responses towardJournal of leukocyte biology · 2017Article
- Article
- Article
- Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.PLoS pathogens · 2015Article
- Interferon-γ inhibits group B Streptococcus survival within human endothelial cells.Memorias do Instituto Oswaldo Cruz · 2014Article
- Comprehensive multiplexed protein quantitation delineates eosinophilic and neutrophilic experimental asthma.BMC pulmonary medicine · 2014Article
- Septic arthritis: immunopathogenesis, experimental models and therapy.The journal of venomous animals and toxins including tropical diseases · 2014Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the role of interferon-gamma (IFN-gamma) in Staphylococcus aureus infection, we investigated the effects of supplementation with and neutralization of IFN-gamma during septicaemia and arthritis in a murine model. In vivo administration of IFN-gamma both before and after bacterial inoculation significantly decreased mortality on one hand but enhanced the development of arthritis on the other. Treatment of mice with anti-IFN-gamma monoclonal antibodies (mAb) before and after bacterial inoculation did not significantly influence the survival rate but decreased the frequency and severity of arthritis. The beneficial effect of supplementation with IFN-gamma on septicaemia was correlated to the increased phagocytosis and bacterial clearance from liver and kidneys. The down-regulation of the development of arthritis by anti-IFN-gamma mAb was accompanied by the decreased serum tumour necrosis factor-alpha, interleukin-6 and interleukin-1 beta levels. These results demonstrate a significant role for IFN-gamma in simultaneous protection against septicaemia but promotion for the development of septic arthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.