ArticleBiophysical journal1998
Steady-state compartmentalization of lipid membranes by active proteins.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Ion channels can be allosterically regulated by membrane domains near a de-mixing critical point.The Journal of general physiology · 2018Article
- A Rationale for Mesoscopic Domain Formation in Biomembranes.Biomolecules · 2018Article
- Dynamic Scaling of Exosome Sizes.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Structure of archaerhodopsin-2 at 1.8 Å resolution.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Is the fluid mosaic (and the accompanying raft hypothesis) a suitable model to describe fundamental features of biological membranes? What may be missing?Frontiers in plant science · 2013Review
- Lipids, curvature, and nano-medicine.European journal of lipid science and technology : EJLST · 2011Article
- Model answers to lipid membrane questions.Cold Spring Harbor perspectives in biology · 2011Review
- Near-critical fluctuations and cytoskeleton-assisted phase separation lead to subdiffusion in cell membranes.Biophysical journal · 2011Article
- Effect of energy metabolism on protein motility in the bacterial outer membrane.Biophysical journal · 2009Article
- Modeling kinetics of subcellular disposition of chemicals.Chemical reviews · 2009Review
- Electrostatic and electrokinetic contributions to the elastic moduli of a driven membrane.The European physical journal. E, Soft matter · 2009Article
- What do diffusion measurements tell us about membrane compartmentalisation? Emergence of the role of interprotein interactions.Journal of chemical biology · 2008Article
- A macroscopic description of lipid bilayer phase transitions of mixed-chain phosphatidylcholines: chain-length and chain-asymmetry dependence.Biophysical journal · 2001Article
- PMP1 18-38, a yeast plasma membrane protein fragment, binds phosphatidylserine from bilayer mixtures with phosphatidylcholine: a (2)H-NMR study.Biophysical journal · 2000Article
- A model for membrane patchiness: lateral diffusion in the presence of barriers and vesicle traffic.Biophysical journal · 1999Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a simple microscopic model of lipid-protein interactions, based on the hydrophobic matching principle, we study some generic aspects of lipid-membrane compartmentalization controlled by a dispersion of active integral membrane proteins. The activity of the proteins is simulated by conformational excitations governed by an external drive, and the deexcitation is controlled by interaction of the protein with its lipid surroundings. In response to the flux of energy into the proteins from the environment and the subsequent dissipation of energy into the lipid bilayer, the lipid-protein assembly reorganizes into a steady-state structure with a typical length scale determined by the strength of the external drive. In the specific case of a mixed dimyristoylphosphatidylcholine-distearoylphosphatidylcholine bilayer in the gel-fluid coexistence region, it is shown explicitly by computer simulation that the activity of an integral membrane protein can lead to a compartmentalization of the lipid-bilayer membrane. The compartmentalization is related to the dynamical process of phase separation and lipid domain formation.
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