ArticleThe Biochemical journal1998
Cloning and characterization of a novel sequence-specific single-stranded-DNA-binding protein.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation.Communications biology · 2024Pooled it
- Single-stranded DNA-binding proteins are essential components of the architectural LDB1 protein complex.Molecular cell · 2025Article
- Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation.Scientific reports · 2023Article
- The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster.PLoS biology · 2023Article
- Crystal structure of the LUFS domain of human single-stranded DNA binding Protein 2 (SSBP2).Protein science : a publication of the Protein Society · 2019Article
- Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells.Stem cell research & therapy · 2016Article
- Article
- SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate.RNA (New York, N.Y.) · 2014Article
- Silk gland factor-2, involved in fibroin gene transcription, consists of LIM homeodomain, LIM-interacting, and single-stranded DNA-binding proteins.The Journal of biological chemistry · 2013Article
- SSDP cofactors regulate neural patterning and differentiation of specific axonal projections.Developmental biology · 2011Article
- Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10.Development (Cambridge, England) · 2011Article
- Transcriptional regulation by CHIP/LDB complexes.PLoS genetics · 2010Article
- ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- The role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizer.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.Molecular and cellular biology · 2005Article
- SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells.Oncogene · 2005Article
- Mutations of RAI1, a PHD-containing protein, in nondeletion patients with Smith-Magenis syndrome.Human genetics · 2004Article
- The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function.BMC genomics · 2003Article
- Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The promoter region of the chicken alpha2(I) collagen gene contains a pyrimidine-rich element that is well conserved in different mammalian species. This sequence can also form an unusual DNA structure as shown by its sensitivity to SI nuclease in vitro and it lies in a region that is DNase I-hypersensitive only when this promoter is active. We have recently reported that fibroblast nuclear proteins, including chicken Y-box-binding protein 1, bind to this single-stranded pyrimidine-rich sequence. Here we report the isolation, from a chick embryo fibroblast cDNA expression library, of a partial cDNA clone encoding a previously unknown protein, designated SSDP (sequence-specific single-stranded DNA-binding protein), that binds this single-stranded sequence. This clone contains 1199 bp of chicken sequence and has a single long open reading frame that encodes 284 amino acid residues. The affinity-purified recombinant protein encoded by this cDNA binds sequence-specifically to the single-stranded pyrimidine sequence. This cDNA sequence lacks significant similarity to any known gene in the data banks, but it is highly conserved in expressed sequence tags derived from both mouse and human. The corresponding amino acid sequence is remarkably conserved, having 97% identity with mouse and human expressed sequences. The corresponding mRNA is approx. 1800 nt in length and is expressed in both fibroblasts and chondrocytes. The high affinity of this protein for this conserved pyrimidine-rich region suggests that it might be involved in the transcriptional regulation of the alpha2(I) collagen gene.
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Registered trials
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