ArticleMammalian genome : official journal of the International Mammalian Genome Society1998
Molecular cloning of a novel mouse gene with predominant muscle and neural expression.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
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- The role of reticulons in neurodegenerative diseases.Neuromolecular medicine · 2014Review
- Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.Diabetes · 2009Article
- Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.The Journal of biological chemistry · 2008Article
- Tissue specificity and regulation of the N-terminal diversity of reticulon 3.The Biochemical journal · 2005Article
- Sockeye: a 3D environment for comparative genomics.Genome research · 2004Article
- Nspl1, a new Z-band-associated protein.Journal of muscle research and cell motility · 1999Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because numerous diseases affect the muscle and nervous systems, it is important to identify and characterize genes that may play functional roles in these tissues. Sequence analysis of a 106-kb region of human Chromosome (Chr) 19q13.2 revealed a novel gene with homology to the Neuroendocrine-specific protein (NSP), and it has, therefore, been designated NSP-like 1 (Nspl1). We isolated the mouse homolog of this gene and performed extensive expression analysis of both the mouse and human genes. The mouse Nspl1 gene is alternatively spliced to produce two major transcripts: a 2.1-kb mRNA that is expressed at highest levels in the brain, and a 1.2-kb transcript that is primarily expressed in muscle. The larger message contains 10 exons, whereas the smaller transcript contains 7 exons. The last 6 exons, which are present in both transcripts, share significant amino acid sequence identity with the endoplasmic reticulum-bound portion of NSP. Mouse and human Nspl1/NSPL1 genes have expression patterns that are similar to that of the dystrophin gene. In addition, the putative regulatory domains of Nspl1 appear similar in composition and distribution to the defined dystrophin regulatory sequences.
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