ArticleMolecular biology of the cell1998
Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Polymeric immunoglobulin receptor (pIgR) in cancer.Journal of cancer research and clinical oncology · 2023Review
- Immunoglobin A Deficiency and Squamous Cell Carcinoma With a Rare Presentation as Anal Cancer.Journal of medical cases · 2022Article
- Intra- and trans-cellular delivery of enzymes by direct conjugation with non-multivalent anti-ICAM molecules.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Distinct subcellular trafficking resulting from monomeric vs multimeric targeting to endothelial ICAM-1: implications for drug delivery.Molecular pharmaceutics · 2014Article
- Article
- The SCHOOL of nature: I. Transmembrane signaling.Self/nonself · 2010Article
- Receptor complexes cotransported via polarized endocytic pathways form clusters with distinct organizations.Molecular biology of the cell · 2007Article
- Cholesterol-sensitive modulation of transcytosis.Molecular biology of the cell · 2007Article
- Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor.Experimental cell research · 2007Article
- Antibodies to the polymeric immunoglobulin receptor with different binding and trafficking patterns.American journal of respiratory cell and molecular biology · 2005Article
- Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways.The Journal of cell biology · 2005Article
- Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.Molecular biology of the cell · 2004Article
- Physiology of IgA and IgA deficiency.Journal of clinical immunology · 2001Review
- Expression, purification and biochemical characterization of recombinant murine secretory component: a novel tool in mucosal immunology.The Biochemical journal · 1999Article
- Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals.Molecular biology of the cell · 1999Article
- Epithelial transcytosis of immunoglobulins.Journal of mammary gland biology and neoplasia · 1998Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Binding of dimeric immunoglobulin (Ig)A to the polymeric Ig receptor (pIgR) stimulates transcytosis of pIgR across epithelial cells. Through the generation of a series of pIgR chimeric constructs, we have tested the ability of ligand to promote receptor dimerization and the subsequent role of receptor dimerization on its intracellular trafficking. Using the cytoplasmic domain of the T cell receptor-zeta chain as a sensitive indicator of receptor oligomerization, we show that a pIgR:zeta chimeric receptor expressed in Jurkat cells initiates a zeta-specific signal transduction cascade when exposed to dimeric or tetrameric IgA, but not when exposed to monomeric IgA. In addition, we replaced the pIgR's transmembrane domain with that of glycophorin A to force dimerization or with a mutant glycophorin transmembrane domain to prevent dimerization. Forcing dimerization stimulated transcytosis of the chimera, whereas preventing dimerization abolished ligand-stimulated transcytosis. We conclude that binding of dimeric IgA to the pIgR induces its dimerization and that this dimerization is necessary and sufficient to stimulate pIgR transcytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.