ArticleMolecular biology of the cell1998
Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 200 citations in OpenAlex.
- Trophoblast differentiation in the bovine placenta.The Journal of reproduction and development · 2026Review
- Temporal myc dynamics permit mitotic bypass, promoting polyploid phenotypes.Cancer letters · 2025Review
- Effects of oxycodone on placental lineages: Evidence from the transcriptome profile of mouse trophoblast giant cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation.Nature communications · 2024Article
- Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells.Molecular biology of the cell · 2022Article
- Molecular regulation of trophoblast stem cell self-renewal and giant cell differentiation by the Hippo components YAP and LATS1.Stem cell research & therapy · 2022Article
- Communal living: the role of polyploidy and syncytia in tissue biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Review
- Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction.PloS one · 2020Article
- Extracellular glucose levels in cultures of undifferentiated mouse trophoblast stem cells affect gene expression during subsequent differentiation with replicable cell line-dependent variation.The Journal of reproduction and development · 2019Article
- Genome amplification and cellular senescence are hallmarks of human placenta development.PLoS genetics · 2018Article
- Dynamic changes in gene expression and signalling during trophoblast development in the horseReproduction (Cambridge, England) · 2018Article
- Nucleosomes of polyploid trophoblast giant cells mostly consist of histone variants and form a loose chromatin structure.Scientific reports · 2018Article
- Mammalian endoreplication emerges to reveal a potential developmental timer.Cell death and differentiation · 2018Review
- Amitosis of Polyploid Cells Regenerates Functional Stem Cells in the Drosophila Intestine.Cell stem cell · 2017Article
- Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells Despite FGF4.Biology of reproduction · 2016Article
- Cdk12 is essential for embryonic development and the maintenance of genomic stability.Cell death and differentiation · 2016Article
- CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties.Cell adhesion & migration · 2016Article
- Signaling pathways in mouse and human trophoblast differentiation: a comparative review.Cellular and molecular life sciences : CMLS · 2015Review
- More of a good thing or less of a bad thing: gene copy number variation in polyploid cells of the placenta.PLoS genetics · 2014Article
- Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth.Nature reviews. Molecular cell biology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Differentiation of trophoblast giant cells in the rodent placenta is accompanied by exit from the mitotic cell cycle and onset of endoreduplication. Commitment to giant cell differentiation is under developmental control, involving down-regulation of Id1 and Id2, concomitant with up-regulation of the basic helix-loop-helix factor Hxt and acquisition of increased adhesiveness. Endoreduplication disrupts the alternation of DNA synthesis and mitosis that maintains euploid DNA content during proliferation. To determine how the mammalian endocycle is regulated, we examined the expression of the cyclins and cyclin-dependent kinases during the transition from replication to endoreduplication in the Rcho-1 rat choriocarcinoma cell line. We cultured these cells under conditions that gave relatively synchronous endoreduplication. This allowed us to study the events that occur during the transition from the mitotic cycle to the first endocycle. With giant cell differentiation, the cells switched cyclin D isoform expression from D3 to D1 and altered several checkpoint functions, acquiring a relative insensitivity to DNA-damaging agents and a coincident serum independence. The initiation of S phase during endocycles appeared to involve cycles of synthesis of cyclins E and A, and termination of S was associated with abrupt loss of cyclin A and E. Both cyclins were absent from gap phase cells, suggesting that their degradation may be necessary to allow reinitiation of the endocycle. The arrest of the mitotic cycle at the onset of endoreduplication was associated with a failure to assemble cyclin B/p34(cdk1) complexes during the first endocycle. In subsequent endocycles, cyclin B expression was suppressed. Together these data suggest several points at which cell cycle regulation could be targeted to shift cells from a mitotic to an endoreduplicative cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.