ArticleMolecular biology of the cell1998
beta1-integrin cytoplasmic subdomains involved in dominant negative function.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates.Cancers · 2020Review
- Focal adhesions are essential to drive zebrafish heart valve morphogenesis.The Journal of cell biology · 2019Article
- β1 integrin is a crucial regulator of pancreatic β-cell expansion.Development (Cambridge, England) · 2013Article
- Matrix adhesion polarizes heart progenitor induction in the invertebrate chordate Ciona intestinalis.Development (Cambridge, England) · 2013Article
- Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner.PLoS pathogens · 2009Article
- beta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1.The Journal of biological chemistry · 2009Article
- Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.Molecular biology of the cell · 2005Article
- beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases.EMBO reports · 2004Article
- Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.The Journal of cell biology · 2004Article
- Syndecans in tumor cell adhesion and signaling.Reproductive biology and endocrinology : RB&E · 2004Review
- Alpha4beta1 integrin/ligand interaction inhibits alpha5beta1-induced stress fibers and focal adhesions via down-regulation of RhoA and induces melanoma cell migration.Molecular biology of the cell · 2003Article
- Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain.The Journal of cell biology · 2002Article
- Disruption of C-terminal cytoplasmic domain of betaPS integrin subunit has dominant negative properties in developing Drosophila.Molecular biology of the cell · 2002Article
- Cross talk between beta(1) and alpha(V) integrins: beta(1) affects beta(3) mRNA stability.Molecular biology of the cell · 2001Article
- Differential role of beta(1C) and beta(1A) integrin cytoplasmic variants in modulating focal adhesion kinase, protein kinase B/AKT, and Ras/Mitogen-activated protein kinase pathways.Molecular biology of the cell · 2000Article
- Article
- Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin.The Journal of cell biology · 2000Article
- A cell-free system to study regulation of focal adhesions and of the connected actin cytoskeleton.Molecular biology of the cell · 1999Article
- Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression.The Journal of cell biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
The beta1-integrin cytoplasmic domain consists of a membrane proximal subdomain common to the four known isoforms ("common" region) and a distal subdomain specific for each isoform ("variable" region). To investigate in detail the role of these subdomains in integrin-dependent cellular functions, we used beta1A and beta1B isoforms as well as four mutants lacking the entire cytoplasmic domain (beta1TR), the variable region (beta1COM), or the common region (beta1 deltaCOM-B and beta1 deltaCOM-A). By expressing these constructs in Chinese hamster ovary and beta1 integrin-deficient GD25 cells (Wennerberg et al., J Cell Biol 132, 227-238, 1996), we show that beta1B, beta1COM, beta1 deltaCOM-B, and beta1 deltaCOM-A molecules are unable to support efficient cell adhesion to matrix proteins. On exposure to Mn++ ions, however, beta1B, but none of the mutants, can mediate cell adhesion, indicating specific functional properties of this isoform. Analysis of adhesive functions of transfected cells shows that beta1B interferes in a dominant negative manner with beta1A and beta3/beta5 integrins in cell spreading, focal adhesion formation, focal adhesion kinase tyrosine phosphorylation, and fibronectin matrix assembly. None of the beta1 mutants tested shows this property, indicating that the dominant negative effect depends on the specific combination of common and B subdomains, rather than from the absence of the A subdomain in the beta1B isoform.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.