ArticleAmerican journal of human genetics1998
No evidence for significant linkage between bipolar affective disorder and chromosome 18 pericentromeric markers in a large series of multiplex extended pedigrees.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12.Molecular psychiatry · 2003Article
- Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12.Molecular psychiatry · 2003Article
- Manic-depression genes and the new millennium: poised for discovery.Molecular psychiatry · 2002Review
- The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report.Molecular psychiatry · 2002Article
- Human homolog of the mouse imprinted gene Impact resides at the pericentric region of chromosome 18 within the critical region for bipolar affective disorder.Molecular psychiatry · 2001Article
- Identification of candidate genes for psychiatric disorders on 18p11.Molecular psychiatry · 2000Article
- Genetics of bipolar affective disorder.Current psychiatry reports · 2000Review
- Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.American journal of human genetics · 2000Article
- The role of G proteins in the psychobiology and treatment of affective disorders and their integration with the neurotransmitter hypothesis.Current psychiatry reports · 1999Review
- Molecular linkage studies of bipolar disorder.Dialogues in clinical neuroscience · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Bipolar affective disorder (BP) is a major neuropsychiatric disorder with high heritability and complex inheritance. Previously reported linkage between BP and DNA markers in the pericentromeric region of chromosome 18, with a parent-of-origin effect (linkage was present in pedigrees with paternal transmission and absent in pedigrees with exclusive maternal inheritance), has been a focus of interest in human genetics. We reexamined the evidence in one of the largest samples reported to date (1,013 genotyped individuals in 53 unilineal multiplex pedigrees), using 10 highly polymorphic markers and a range of parametric and nonparametric analyses. There was no evidence for significant linkage between BP and chromosome 18 pericentromeric markers in the sample as a whole, nor was there evidence for significant parent-of-origin effect (pedigrees with paternal transmission were not differentially linked to the implicated chromosomal region). Two-point LOD scores and single-locus sib-pair results gave some support for suggestive linkage, but this was not substantiated by multilocus analysis, and the results were further tempered by multiple test effects. We conclude that there is no compelling evidence for linkage between BP and chromosome 18 pericentromeric markers in this sample.
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