ArticleThe Journal of experimental medicine1998
CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Emerging phagocytosis checkpoints in cancer immunotherapy.Signal transduction and targeted therapy · 2023Review
- CD24-Fc suppression of immune related adverse events in a therapeutic cancer vaccine model of murine neuroblastoma.Frontiers in immunology · 2023Article
- Dendritic cell expression of CD24 contributes to optimal priming of T lymphocytes in lymph nodes.Frontiers in immunology · 2023Article
- CD24 is expressed on FoxP3American journal of translational research · 2022Article
- Elevated hippocampal CD24 in astrocytes participates in neural regeneration possibly via activating SHP2/ERK pathway after experimental traumatic brain injury in mice.American journal of translational research · 2020Article
- CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages.Cell discovery · 2018Article
- CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease.PloS one · 2017Article
- CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases.Clinical reviews in allergy & immunology · 2016Review
- Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells.The Journal of clinical investigation · 2015Article
- Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases.Medicinal research reviews · 2012Review
- A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis.American journal of translational research · 2012Article
- CD24: from A to Z.Cellular & molecular immunology · 2010Review
- CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns.Trends in immunology · 2009Article
- Antigen processing and CD24 expression determine antigen presentation by splenic CD4+ and CD8+ dendritic cells.Immunology · 2008Article
- Further study of anti-ICOS immunotherapy for rat cardiac allograft rejection.Surgery today · 2008Article
- Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts.The Journal of experimental medicine · 2006Article
- Changes in immune responses to antigen applied to tape-stripped skin with CpG-oligodeoxynucleotide in NC/Nga mice.Pharmaceutical research · 2005Article
- CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host.The Journal of experimental medicine · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
It is well established that B7-CD28/CTLA4 interactions play an important role in the induction of T helper cells for T-dependent antibody responses. However, targeted mutation of CD28 does not significantly affect production of IgG and activation of CD4 T helper cells in response to infections by some viruses and nematode parasites. To test whether the CD28-independent induction of Ig class switches requires costimulation by the heat-stable antigen (HSA), we compared T helper cell induction and antibody response in mice deficient for either HSA, CD28, or both genes. We found that after immunization with KLH-DNP, mice deficient for both CD28 and HSA lack DNP-specific IgA and all subtypes of IgG. This deficiency corresponds to a reduced number of effector helper T cells that rapidly produce IL-2, IL-4, and IFN-gamma after in vitro stimulation with carrier antigen KLH. In contrast, priming of T helper cells and Ig class switch are normal in mice deficient with either HSA or CD28 alone. IgM responses are not affected by any of these targeted mutations. These results demonstrate that CD28-independent induction of T helper cells and Ig class-switches requires costimulation by the HSA.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.