ArticleThe Journal of experimental medicine1998
T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis.Developmental and comparative immunology · 2015Article
- T cell CD3ζ deficiency enables multiorgan tissue inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.The Journal of experimental medicine · 2012Article
- Gene expression alterations in immune system pathways in the thymus after exposure to immunosuppressive chemicals.Environmental health perspectives · 2011Article
- Article
- Stoichiometry of the murine gammadelta T cell receptor.The Journal of experimental medicine · 2006Article
- An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor.The Journal of experimental medicine · 2005Article
- A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells.The Journal of experimental medicine · 2004Article
- Fugu rubripes possesses genes for the entire set of the ITAM-bearing transmembrane signal subunits.Immunogenetics · 2003Article
- Activation-induced modification in the CD3 complex of the gammadelta T cell receptor.The Journal of experimental medicine · 2002Article
- Defective expression and tyrosine phosphorylation of the T cell receptor zeta chain in peripheral blood T cells from systemic lupus erythematosus patients.Clinical and experimental immunology · 2002Article
- DAP12 and KAP10 (DAP10)-novel transmembrane adapter proteins of the CD3zeta family.Immunologic research · 2000Review
- Specific requirement for CD3epsilon in T cell development.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zeta family includes zeta, eta, and FcepsilonRIgamma (Fcgamma). Dimers of the zeta family proteins function as signal transducing subunits of the T cell antigen receptor (TCR), the pre-TCR, and a subset of Fc receptors. In mice lacking zeta/eta chains, T cell development is impaired, yet low numbers of CD4+ and CD8+ T cells develop. This finding suggests either that pre-TCR and TCR complexes lacking a zeta family dimer can promote T cell maturation, or that in the absence of zeta/eta, Fcgamma serves as a subunit in TCR complexes. To elucidate the role of zeta family dimers in T cell development, we generated mice lacking expression of all of these proteins and compared their phenotype to mice lacking only zeta/eta or Fcgamma. The data reveal that surface complexes that are expressed in the absence of zeta family dimers are capable of transducing signals required for alpha/beta-T cell development. Strikingly, T cells generated in both zeta/eta-/- and zeta/eta-/--Fcgamma-/- mice exhibit a memory phenotype and elaborate interferon gamma. Finally, examination of different T cell populations reveals that zeta/eta and Fcgamma have distinct expression patterns that correlate with their thymus dependency. A possible function for the differential expression of zeta family proteins may be to impart distinctive signaling properties to TCR complexes expressed on specific T cell populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.