ArticleInfection and immunity1998
Expression of the Candida albicans gene ALS1 in Saccharomyces cerevisiae induces adherence to endothelial and epithelial cells.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 156 citations in OpenAlex.
- Increased fungal burden in the gastrointestinal tract of brain-dead organ donors.Microbiology spectrum · 2025Article
- Article
- Comprehensive genetic analysis of adhesin proteins and their role in virulence of Candida albicans.Genetics · 2021Article
- Review
- Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.PLoS pathogens · 2021Article
- Ozone ultrafine bubble water inhibits the early formation of Candida albicans biofilms.PloS one · 2021Article
- An Amyloid Core Sequence in the Major Candida albicans Adhesin Als1p Mediates Cell-Cell Adhesion.mBio · 2019Article
- Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity.European journal of immunology · 2018Review
- What We Do Not Know about Fungal Cell Adhesion Molecules.Journal of fungi (Basel, Switzerland) · 2018Review
- Community Development betweenmBio · 2018Article
- ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection.International journal of oral science · 2018Article
- Fungal Biofilms: Inside Out.Microbiology spectrum · 2017Review
- Aspergillus fumigatus CalA binds to integrin αNature microbiology · 2016Article
- Human Epithelial Cells Discriminate between Commensal and Pathogenic Interactions with Candida albicans.PloS one · 2016Article
- Candida albicans Biofilm Development and Its Genetic Control.Microbiology spectrum · 2015Article
- Vaccines in the treatment of invasive candidiasis.Virulence · 2015Review
- Functional regions of Candida albicans hyphal cell wall protein Als3 that determine interaction with the oral bacterium Streptococcus gordonii.Microbiology (Reading, England) · 2015Article
- In vitro models of hematogenously disseminated candidiasis.Virulence · 2014Article
- Between Amyloids and Aggregation Lies a Connection with Strength and Adhesion.New journal of science · 2014Article
- Adhesins in human fungal pathogens: glue with plenty of stick.Eukaryotic cell · 2013Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
To identify genes encoding adhesins that mediate the binding of Candida albicans to endothelial cells, a genomic library from this organism was constructed and used to transform Saccharomyces cerevisiae. These transformed organisms were screened for adherence to endothelial cells, and a highly adherent clone was identified. The adherence of this clone to endothelial cells was over 100-fold greater than that of control S. cerevisiae transformed with the empty plasmid. This clone also exhibited enhanced adherence to epithelial cells. The C. albicans gene contained within this clone was found to be ALS1. These results indicate that ALS1 may encode a candidal adhesin.
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Registered trials
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