ArticleInfection and immunity1998
Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut.Cell · 2026Article
- The Ambivalent Nature ofToxins · 2025Review
- Colorectal cancer-associatedJournal of bacteriology · 2025Article
- Complete genome sequence of an enterotoxigenicMicrobiology resource announcements · 2025Article
- Bacteroides fragilis in saliva: investigating links with ulcerative colitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- IntestinalmBio · 2024Article
- Screening and epitope characterization of diagnostic nanobody against total and activatedFrontiers in immunology · 2023Article
- Implications of Gut Microbiota in Epithelial-Mesenchymal Transition and Cancer Progression: A Concise Review.Cancers · 2022Review
- Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2022Review
- The Human Gut Microbiome - A Potential Controller of Wellness and Disease.Frontiers in microbiology · 2018Review
- Gastrointestinal Pathobionts in Pediatric Crohn's Disease Patients.International journal of microbiology · 2018Article
- Next-generation probiotics: the spectrum from probiotics to live biotherapeutics.Nature microbiology · 2017Article
- Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia.PloS one · 2017Article
- Comparison of standard, quantitative and digital PCR in the detection of enterotoxigenic Bacteroides fragilis.Scientific reports · 2016Article
- Article
- PCR Detection of the Bacteroides fragilis Enterotoxin Gene Relies on Robust Primer Design.Journal of clinical microbiology · 2016Article
- A novel mechanism of latency in matrix metalloproteinases.The Journal of biological chemistry · 2015Article
- Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis.The Journal of clinical investigation · 2014Review
- Discerning the role of Bacteroides fragilis in celiac disease pathogenesis.Applied and environmental microbiology · 2012Article
- Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes.Clinical microbiology reviews · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Enterotoxigenic strains of Bacteroides fragilis produce an extracellular metalloprotease toxin (termed fragilysin) which is cytopathic to intestinal epithelial cells and induces fluid secretion and tissue damage in ligated intestinal loops. We report here that the fragilysin gene is contained within a small genetic element termed the fragilysin pathogenicity islet. The pathogenicity islet of B. fragilis VPI 13784 was defined as 6,033 bp in length and contained nearly perfect 12-bp direct repeats near its ends. Sequencing across the ends of the pathogenicity islet from two additional enterotoxigenic strains, along with PCR analysis of 20 additional enterotoxigenic strains, revealed that the islet is inserted at a specific site on the B. fragilis chromosome. The site of integration in three nontoxigenic strains contained a 17-bp GC-rich sequence which was not present in toxigenic strains and may represent a target sequence for chromosomal integration. In addition to the fragilysin gene, we identified an open reading frame encoding a predicted protein with a size and structural features similar to those of fragilysin. The deduced amino acid sequence was 28.5% identical and 56.3% similar to fragilysin and contained a nearly identical zinc-binding motif and methionine-turn region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.