ArticleInfection and immunity1998
Elastase is the only human neutrophil granule protein that alone is responsible for in vitro killing of Borrelia burgdorferi.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Mutant allele knockout with novel CRISPR nuclease promotes myelopoiesis in ELANE neutropenia.Molecular therapy. Methods & clinical development · 2022Article
- Glycine induces enhancement of bactericidal activity of neutrophils.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- Neutrophil Elastase Defects in Congenital Neutropenia.Frontiers in immunology · 2021Review
- Immune Response toCurrent issues in molecular biology · 2021Article
- Super-silent FRET Sensor Enables Live Cell Imaging and Flow Cytometric Stratification of Intracellular Serine Protease Activity in Neutrophils.Scientific reports · 2018Article
- Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen.PloS one · 2016Article
- Neutrophil serine proteases exert proteolytic activity on endothelial cells.Kidney international · 2015Article
- Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.BMC women's health · 2011Article
- Alpha-1 antitrypsin is markedly decreased following pulmonary F. tularensis challenge.Frontiers in cellular and infection microbiology · 2011Article
- Lyme arthritis: current concepts and a change in paradigm.Clinical and vaccine immunology : CVI · 2008Review
- Recruitment of macrophages and polymorphonuclear leukocytes in Lyme carditis.Infection and immunity · 2007Article
- Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host.Infection and immunity · 2006Article
- Human neutrophil calprotectin reduces the susceptibility of Borrelia burgdorferi to penicillin.Infection and immunity · 2006Article
- Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice.Clinical and vaccine immunology : CVI · 2006Article
- Complement receptor 3 binds the Borrelia burgdorferi outer surface proteins OspA and OspB in an iC3b-independent manner.Infection and immunity · 2005Article
- In vitro effects of acellular milk on the bactericidal components of caprine polymorphonuclear neutrophils.Veterinary research communications · 2003Article
- Leptospires are killed in vitro by both oxygen-dependent and -independent reactions.Infection and immunity · 2002Article
- Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants.The American journal of pathology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phagocytosis of Borrelia burgdorferi by human polymorphonuclear leukocytes triggers oxygen-dependent and -independent mechanisms of potentially cidal outcome. Nevertheless, no factor or process has yet been singled out as being borreliacidal. We have studied the B. burgdorferi-killing ability of the myeloperoxidase-H2O2-chloride system and that of primary and secondary granule components in an in vitro assay. We found that neither secondary granule acid extracts nor the chlorinating system could kill these microorganisms, while primary granule extracts were effective. The Borrelia-killing factor was purified to homogeneity and demonstrated to be elastase. Its cidal activity was found to be independent of its proteolytic activity.
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