ArticleInfection and immunity1998
Influence of antibodies in mother's milk on antigenic variation of Giardia lamblia in the murine mother-offspring model of infection.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- "Immunoinformatic Identification of T-Cell and B-Cell Epitopes FromFrontiers in cellular and infection microbiology · 2021Article
- Comparative Pathobiology of the Intestinal Protozoan ParasitesPathogens (Basel, Switzerland) · 2019Review
- Serum levels of zinc, copper, vitamin B12, folate and immunoglobulins in individuals with giardiasis.Iranian journal of public health · 2012Article
- Disruption of antigenic variation is crucial for effective parasite vaccine.Nature medicine · 2010Article
- Arginine deiminase has multiple regulatory roles in the biology of Giardia lamblia.Journal of cell science · 2008Article
- Experimental infections of neonatal mice with cysts of Giardia lamblia clone GS/M-83-H7 are associated with an antigenic reset of the parasite.Infection and immunity · 2004Article
- Systemic and mucosal responses to oral administration of excretory and secretory antigens from Giardia intestinalis.Clinical and diagnostic laboratory immunology · 2004Article
- Interleukin-6-deficient mice are highly susceptible to Giardia lamblia infection but exhibit normal intestinal immunoglobulin A responses against the parasite.Infection and immunity · 2003Article
- Central importance of immunoglobulin A in host defense against Giardia spp.Infection and immunity · 2002Article
- vsp gene expression by Giardia lamblia clone GS/M-83-H7 during antigenic variation in vivo and in vitro.Infection and immunity · 2001Article
- Immune response to Giardia duodenalis.Clinical microbiology reviews · 2000Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, neonatal ZU.ICR mice and their mothers were infected with trophozoites of Giardia lamblia clone GS/M-83-H7 expressing the variant surface protein (VSP) H7. The infection experiments included a detailed analysis of the specificities of anti-Giardia immunoglobulin A (IgA) antibodies in mother's milk and a determination of the effects of the milk antibodies on both the growth of the parasite during in vitro cultivation and colonization of the parasite within the intestine of suckling offspring. These investigations revealed that transiently emerging milk IgA antibodies against a variant-specific 314-amino-acid N-terminal region of VSP H7 exhibit a strong parasiticidal effect on VSP H7-type trophozoites both in vitro and in vivo. These findings indicated that parasiticidal effects of local IgA antibodies against the N-terminal part of VSP H7 select for new variant types within the intestinal parasite population of suckling mice. The selective influence of such antibodies promotes in vivo antigenic variation of G. lamblia clone GS/M-83-H7 and modulates the early course of parasite infection in these animals.
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