ArticleMolecular and cellular biology1998
DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 108 citations in OpenAlex.
- Article
- MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis.Biology · 2020Review
- Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface.Biochemistry · 2020Article
- Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways.Frontiers in cell and developmental biology · 2020Review
- Budding YeastG3 (Bethesda, Md.) · 2018Article
- Regulation of Protein Interactions byMolecular & cellular proteomics : MCP · 2017Article
- ChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum.BMC microbiology · 2017Article
- Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.Genes & development · 2015Article
- Coupling mRNA synthesis and decay.Molecular and cellular biology · 2014Review
- hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.Cancer research · 2014Article
- Septin-containing barriers control the differential inheritance of cytoplasmic elements.Cell reports · 2013Article
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- MOB control: reviewing a conserved family of kinase regulators.Cellular signalling · 2011Review
- CDK-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans.Molecular biology of the cell · 2011Article
- The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1.The Journal of cell biology · 2011Article
- Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.Molecular and cellular biology · 2010Article
- Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.The EMBO journal · 2010Article
- The structural basis for deadenylation by the CCR4-NOT complex.Protein & cell · 2010Review
- The Drosophila Fry protein interacts with Trc and is highly mobile in vivo.BMC developmental biology · 2010Article
- DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The DBF2 gene of the budding yeast Saccharomyces cerevisiae encodes a cell cycle-regulated protein kinase that plays an important role in the telophase/G1 transition. As a component of the multisubunit CCR4 transcriptional complex, DBF2 is also involved in the regulation of gene expression. We have found that MOB1, an essential protein required for a late mitotic event in the cell cycle, genetically and physically interacts with DBF2. DBF2 binds MOB1 in vivo and can bind it in vitro in the absence of other yeast proteins. We found that the expression of MOB1 is also cell cycle regulated, its expression peaking slightly before that of DBF2 at the G2/M boundary. While overexpression of DBF2 suppressed phenotypes associated with mob1 temperature-sensitive alleles, it could not suppress a mob1 deletion. In contrast, overexpression of MOB1 suppressed phenotypes associated with a dbf2-deleted strain and suppressed the lethality associated with a dbf2 dbf20 double deletion. A mob1 temperature-sensitive allele with a dbf2 disruption was also found to be synthetically lethal. These results are consistent with DBF2 acting through MOB1 and aiding in its function. Moreover, the ability of temperature-sensitive mutated versions of the MOB1 protein to interact with DBF2 was severely reduced, confirming that binding of DBF2 to MOB1 is required for a late mitotic event. While MOB1 and DBF2 were found to be capable of physically associating in a complex that did not include CCR4, MOB1 did interact with other components of the CCR4 transcriptional complex. We discuss models concerning the role of DBF2 and MOB1 in controlling the telophase/G1 transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.