ArticleMolecular and cellular biology1998
Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 81 citations in OpenAlex.
- Terminal deoxynucleotidyl transferase: Properties and applications.Engineering microbiology · 2025Review
- Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks.Journal of molecular biology · 2022Review
- A Mechanism to Minimize Errors during Non-homologous End Joining.Molecular cell · 2020Article
- Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining.Science (New York, N.Y.) · 2018Article
- HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.Molecular cell · 2014Article
- XRCC4's interaction with XLF is required for coding (but not signal) end joining.Nucleic acids research · 2012Article
- Polymerases in nonhomologous end joining: building a bridge over broken chromosomes.Antioxidants & redox signaling · 2011Review
- The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.Annual review of biochemistry · 2010Review
- Accessibility of chromosomal recombination breaks in nuclei of wild-type and DNA-PKcs-deficient cells.DNA repair · 2009Article
- Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.Molecular cell · 2009Article
- Article
- LINE-1 methylation status of endogenous DNA double-strand breaks.Nucleic acids research · 2008Article
- Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Initiation of V(D)J recombination in zebrafish (Danio rerio) ovaries.Molecular immunology · 2007Article
- V(D)J recombination in zebrafish: Normal joining products with accumulation of unresolved coding ends and deleted signal ends.Molecular immunology · 2007Article
- XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps.The EMBO journal · 2007Article
- Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination.Nucleic acids research · 2007Article
- Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity.Leukemia · 2005Article
- Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent.Molecular and cellular biology · 2005Article
- Processing of DNA for nonhomologous end-joining by cell-free extract.The EMBO journal · 2005Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The V(D)J recombinase recognizes a pair of immunoglobulin or T-cell receptor gene segments flanked by recombination signal sequences and introduces double-strand breaks, generating two signal ends and two coding ends. Broken coding ends were initially identified as covalently closed hairpin DNA molecules. Before recombination, however, the hairpins must be opened and the ends must be modified by nuclease digestion and N-region addition. We have now analyzed nonhairpin coding ends associated with various immunoglobulin gene segments in cells undergoing V(D)J recombination. We found that these broken DNA ends have different nonrandom 5'-strand deletions which were characteristic for each locus examined. These deletions correlate well with the sequence characteristics of coding joints involving these gene segments. In addition, unlike broken signal ends, these nonhairpin coding-end V(D)J recombination reaction intermediates have 3' overhanging ends. We discuss the implications of these results for models of how sequence modifications occur during coding-joint formation.
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