ArticleAntimicrobial agents and chemotherapy1998
Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 59 citations in OpenAlex.
- Update on new antivirals under development for the treatment of double-stranded DNA virus infections.Clinical pharmacology and therapeutics · 2010Review
- Fluorinated Nucleosides: Synthesis and Biological Implication.Journal of fluorine chemistry · 2008Article
- Development of a novel mouse model to evaluate drug candidates against hepatitis B virus.Antiviral chemistry & chemotherapy · 2007Article
- Effects of pyrimidine and purine analog combinations in the duck hepatitis B virus infection model.Antimicrobial agents and chemotherapy · 2003Article
- Comparison of anti-hepatitis B virus activities of lamivudine and clevudine by a quantitative assay.Antimicrobial agents and chemotherapy · 2003Article
- Rebound of hepatitis B virus replication in HepG2 cells after cessation of antiviral treatment.Journal of virology · 2002Article
- Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro.Antimicrobial agents and chemotherapy · 2002Article
- Current Options for the Therapy of Chronic Hepatitis B Infection.Current infectious disease reports · 2001Article
- The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance.The Journal of clinical investigation · 2001Article
- Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis.Journal of virology · 2001Article
- Characterization of the antiviral effect of 2',3'-dideoxy-2', 3'-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model.Antimicrobial agents and chemotherapy · 2000Article
- Active site polymerase inhibitor nucleotides (ASPINs): Potential agents for chronic HBV cure regimens.Antiviral chemistry & chemotherapyReview
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The antiviral activity of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU), a novel L-nucleoside analog of thymidine known to be an inhibitor of hepatitis B virus (HBV) replication in hepatoma cells (2.2.1.5 cell line), was evaluated in the duck HBV (DHBV) model. Short-term oral administration (5 days) of L-FMAU (40 mg/kg of body weight/day) to experimentally infected ducklings induced a significant decrease in the level of viremia. This antiviral effect was sustained in animals when therapy was prolonged for 8 days. The histological study showed no evidence of liver toxicity in the L-FMAU-treated group. By contrast, microvesicular steatosis was found in the livers of dideoxycytidine-treated animals. L-FMAU administration in primary duck hepatocyte cultures infected with DHBV induced a dose-dependent inhibition of both virion release in culture supernatants and intracellular viral DNA synthesis, without clearance of viral covalently closed circular DNA. By using a cell-free system for the expression of an enzymatically active DHBV reverse transcriptase, it was shown that L-FMAU triphosphate exhibits an inhibitory effect on the incorporation of dAMP in the viral DNA primer. Thus, our data demonstrate that L-FMAU inhibits DHBV replication in vitro and in vivo. Long-term administration of L-FMAU for the eradication of viral infection in animal models of HBV infection should be evaluated.
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