ArticleJournal of neurology, neurosurgery, and psychiatry1998
Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome.
Article in Journal of neurology, neurosurgery, and psychiatry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Long COVID - a critical disruption of cholinergic neurotransmission?Bioelectronic medicine · 2025Review
- Diagnostic accuracy of the lactate stress test for detecting mitochondrial disorders: Systematic review and meta-analysis.Heliyon · 2024Article
- Functional and Morphological Differences of Muscle Mitochondria in Chronic Fatigue Syndrome and Post-COVID Syndrome.International journal of molecular sciences · 2024Article
- The plasma metabolome of long COVID patients two years after infection.Scientific reports · 2023Article
- Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome.Scientific reports · 2019Article
- Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome.Physiological reports · 2019Article
- Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome.European journal of translational myology · 2018Article
- Understanding Muscle Dysfunction in Chronic Fatigue Syndrome.Journal of aging research · 2016Review
- Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms.World journal of methodology · 2015Review
- The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders.BMC medicine · 2015Article
- Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).Current neuropharmacology · 2014Article
- Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.Metabolic brain disease · 2014Article
- A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome.Metabolic brain disease · 2013Review
- Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.Molecular neurobiology · 2013Review
- Review
- Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Potential role of pioglitazone, caffeic acid and their combination against fatigue syndrome-induced behavioural, biochemical and mitochondrial alterations in mice.Inflammopharmacology · 2010Article
- Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.Journal of muscle research and cell motility · 2007Review
- Enterovirus related metabolic myopathy: a postviral fatigue syndrome.Journal of neurology, neurosurgery, and psychiatry · 2003Article
- Chronic fatigue syndrome: an update.Sports medicine (Auckland, N.Z.) · 2001Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the proportions of type 1 and type 2 muscle fibres and the degree of muscle fibre atrophy and hypertrophy in patients with chronic fatigue syndrome in relation to lactate responses to exercise, and to determine to what extent any abnormalities found might be due to inactivity.
methodsQuadriceps needle muscle biopsies were obtained from 105 patients with chronic fatigue syndrome and the proportions of type 1 and 2 fibres and fibre atrophy and hypertrophy factors were determined from histochemical preparations, using a semiautomated image analysis system. Forty one randomly selected biopsies were also examined by electron microscopy. Lactate responses to exercise were measured in the subanaerobic threshold exercise test (SATET).
resultsInactivity would be expected to result in a shift to type 2 fibre predominance and fibre atrophy, but type 1 predominance (23%) was more common than type 2 predominance (3%), and fibre atrophy was found in only 10.4% of cases. Patients with increased lactate responses to exercise did have significantly fewer type 1 muscle fibres (p<0.043 males, p<0.0003 females), but there was no evidence that this group was less active than the patients with normal lactate responses. No significant ultrastructural abnormalities were found.
conclusionMuscle histometry in patients with chronic fatigue syndrome generally did not show the changes expected as a result of inactivity. However, patients with abnormal lactate responses to exercise had a significantly lower proportion of mitochondria rich type 1 muscle fibres.
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