ArticleJournal of neurology, neurosurgery, and psychiatry1998
A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia?
Article in Journal of neurology, neurosurgery, and psychiatry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Thai Guideline for Nuclear Medicine Investigations of Neurocognitive Disorders: Nuclear Medicine Society of Thailand, the Neurological Society of Thailand, and Thai Medical Physicist Society Collaboration.Diagnostics (Basel, Switzerland) · 2024Guideline
- Regional cerebral blood flow single photon emission computed tomography for detection of Frontotemporal dementia in people with suspected dementia.The Cochrane database of systematic reviews · 2015Pooled it
- The Legacy of the TTASAAN Report-Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I.Frontiers in neurology · 2021Review
- MR Elastography Demonstrates Unique Regional Brain Stiffness Patterns in Dementias.AJR. American journal of roentgenology · 2017Article
- Combining SPECT and Quantitative EEG Analysis for the Automated Differential Diagnosis of Disorders with Amnestic Symptoms.Frontiers in aging neuroscience · 2017Article
- Neuroimaging referral for dementia diagnosis: The specialist's perspective in Ireland.Alzheimer's & dementia (Amsterdam, Netherlands) · 2015Article
- Is the cerebellum the optimal reference region for intensity normalization of perfusion MR studies in early Alzheimer's disease?PloS one · 2013Article
- Functional correlates of instrumental activities of daily living in mild Alzheimer's disease.Neurobiology of aging · 2012Article
- Imaging improves diagnosis of dementia with lewy bodies.Psychiatry investigation · 2009Article
- Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementia.Journal of the International Neuropsychological Society : JINS · 2009Article
- Neuroimaging in dementia.Seminars in neurology · 2008Review
- [Diagnostic value of multislice perfusion CT in dementia patients].Der Radiologe · 2008Article
- Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry · 2007Article
- CT perfusion as a useful tool in the evaluation of leuko-araiosis.Biomedical imaging and intervention journal · 2006Article
- Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry · 2005Article
- Correlations of hippocampal atrophy and focal low-frequency magnetic activity in Alzheimer disease: volumetric MR imaging-magnetoencephalographic study.AJNR. American journal of neuroradiology · 2003Article
- Brain SPET perfusion in early Alzheimer's disease: where to look?European journal of nuclear medicine and molecular imaging · 2002Article
- Diffuse Lewy Body Disease.Current treatment options in neurology · 2001Article
- Vascular dementia: Diagnostic criteria and supplementary exams. Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology. Part I.Dementia & neuropsychologiaReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo provide the clinician with a guide to the clinical utility of 99mTc-HMPAO single photon emission computed tomography (SPECT) and to the interpretation of specific test results in the differential diagnosis of dementia.
methodsThree hundred and sixty three patients with dementia were studied prospectively for a median three (range 1-6) years and classified into disease groups on the basis of established clinical criteria. The degree to which different patterns of cerebral blood flow (CBF) abnormality found on 99mTc-HMPAO SPECT imaging at the time of initial patient presentation modified clinical diagnoses was determined by calculating the likelihood ratios for pairwise disease group comparisons. The optimal clinical usage of 99mTc-HMPAO SPECT was determined by calculating the percentage of significant test results for each pairwise disease group comparison.
resultsBilateral posterior CBF abnormality was found to significantly increase the odds of a patient having Alzheimer's disease as opposed to vascular dementia or frontotemporal dementia. Bilateral anterior CBF abnormality significantly increased the odds of a patient having frontotemporal dementia as opposed to Alzheimer's disease, vascular dementia, or Lewy body disease. "Patchy" CBF changes significantly increased the odds of a patient having vascular dementia as opposed to Alzheimer's disease. Unilateral anterior, unilateral anterior plus unilateral posterior, and generalised CBF abnormality failed to contribute to the differentiation of any of these forms of dementia.
conclusions99mTc-HMPAO SPECT was found to be most useful in distinguishing Alzheimer's disease from vascular dementia and fronto temporal dementia, and least useful in differentiating between Alzheimer's disease and Lewy body disease, and between vascular dementia, frontotemporal dementia, and progressive aphasia. It is suggested that CBF SPECT should be used selectively and as an adjunct to clinical evaluation and CT.
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