ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Vagotomy-induced enhancement of mechanical hyperalgesia in the rat is sympathoadrenal-mediated.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 102 citations in OpenAlex.
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- Peripheral Beta-2 Adrenergic Receptors Mediate the Sympathetic Efferent Activation from Central Nervous System to Splenocytes in a Mouse Model of Fibromyalgia.International journal of molecular sciences · 2023Article
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain.International journal of molecular sciences · 2020Article
- Allodynia by Splenocytes From Mice With Acid-Induced Fibromyalgia-Like Generalized Pain and Its Sexual Dimorphic Regulation by Brain Microglia.Frontiers in neuroscience · 2020Article
- Chronic Diffuse Pain and Functional Gastrointestinal Disorders After Traumatic Stress: Pathophysiology Through a Polyvagal Perspective.Frontiers in medicine · 2018Article
- ATP release mechanisms of endothelial cell-mediated stimulus-dependent hyperalgesia.The journal of pain · 2014Article
- Fibromyalgia and sleep in animal models: a current overview and future directions.Current pain and headache reports · 2014Review
- Stress in the adult rat exacerbates muscle pain induced by early-life stress.Biological psychiatry · 2013Article
- Role of endothelial cells in antihyperalgesia induced by a triptan and β-blocker.Neuroscience · 2013Article
- Independent contributions of alcohol and stress axis hormones to painful peripheral neuropathy.Neuroscience · 2013Article
- Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test: Involvement of Peripheral β -Adrenoceptors.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Randall-Selitto test: a new approach for the detection of neuropathic pain after spinal cord injury.Journal of neurotrauma · 2012Article
- Potential autonomic risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case-control study.The journal of pain · 2011Article
- A peripheral adrenoceptor-mediated sympathetic mechanism can transform stress-induced analgesia into hyperalgesia.Anesthesiology · 2011Article
- Psychological stress induces temporary masticatory muscle mechanical sensitivity in rats.Journal of biomedicine & biotechnology · 2011Article
- Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Effects of 17beta-estradiol on responses of viscerosomatic convergent thalamic neurons in the ovariectomized female rat.Journal of neurophysiology · 2009Article
- Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.The European journal of neuroscience · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We have recently shown that subdiaphragmatic vagotomy enhances bradykinin-induced hyperalgesic behavior and decreases baseline paw withdrawal threshold to mechanical stimulation of the hindpaw skin in rats by a peripheral mechanism. To elucidate the underlying mechanism, we studied whether lesions of efferent neuroendocrine pathways could prevent or reverse the potentiating effect of vagotomy. In groups of sham-vagotomized or vagotomized rats, we surgically removed or denervated the adrenal medulla. Bradykinin was injected intradermally into the skin of the dorsal surface of the rat hindpaw. Threshold of paw withdrawal to mechanical stimulation of the skin was measured. Vagotomy induced a decrease in mechanical baseline paw withdrawal threshold and enhancement of bradykinin-induced mechanical hyperalgesic behavior, both of which were maintained over the 5 week testing period. Adrenal enucleation or denervation of the adrenal gland by suprarenal ganglionectomy prevented vagotomy-induced decrease in baseline paw withdrawal threshold and enhancement of bradykinin-induced hyperalgesia. In animals that had a demonstrated decrease in baseline paw withdrawal threshold and enhancement of bradykinin-induced hyperalgesia 2 weeks after vagotomy, additional denervation of the adrenal medulla significantly reversed these effects over a 3 week period. These results imply that both the decrease in baseline paw withdrawal threshold and enhancement of bradykinin-induced hyperalgesic behavior after vagotomy are dependent on a hormonal signal released from the adrenal medulla and suggest a novel mechanism of sensitization of cutaneous nociceptors.
Indexed as
Identifiers
9526021PMC6792577W1535517466What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.