ArticleJournal of virology1998
cis-Acting sequences required for simian foamy virus type 1 vectors.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Review
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- Regulation of foamy virus protease activity by viral RNA: a novel and unique mechanism among retroviruses.Journal of virology · 2011Article
- Review
- Foamy virus vectors for gene transfer.Expert opinion on biological therapy · 2009Review
- Role of the foamy virus Pol cleavage site in viral replication.Journal of virology · 2007Article
- Foamy virus vector integration sites in normal human cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- RNA and protein requirements for incorporation of the Pol protein into foamy virus particles.Journal of virology · 2005Article
- Improved primate foamy virus vectors and packaging constructs.Journal of virology · 2002Article
- A new RNA element located in the coding region of a murine endogenous retrovirus can functionally replace the Rev/Rev-responsive element system in human immunodeficiency virus type 1 Gag expression.Journal of virology · 2001Article
- Palindromic sequence plays a critical role in human foamy virus dimerization.Journal of virology · 2001Article
- Complex effects of deletions in the 5' untranslated region of primate foamy virus on viral gene expression and RNA packaging.Journal of virology · 2000Article
- Multiple integrations of human foamy virus in persistently infected human erythroleukemia cells.Journal of virology · 2000Article
- Persistent zoonotic infection of a human with simian foamy virus in the absence of an intact orf-2 accessory gene.Journal of virology · 1999Article
- Packaging cell lines for simian foamy virus type 1 vectors.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have constructed a series of vectors based on simian foamy virus type 1 (SFV-1) to define the minimum cis-acting elements required for gene transfer. To characterize these vectors, we inserted the coding sequence of the bacterial lacZ gene linked to the cytomegalovirus immediate-early gene promoter. Introduction of a deletion mutation in the leader region between the 5' long terminal repeat and the start of the gag gene at position 1659 to 1694 completely abrogated gene transfer by the SFV-1 vector. Deletion of 39 nucleotides from position 1692 to 1731 in the leader region resulted in a significant reduction in the transducing-particle titer. Furthermore, we have identified a second cis-acting element located at the 3' end of the pol gene between position 6486 and 6975 to be critical for SFV-1 vector transduction. These results identify the two important cis-acting elements required for SFV-1 vector construction, and the finding of a cis-acting element in the pol gene is unique among retroviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.