ArticleJournal of virology1998
Genotype-specific complementation of hepatitis delta virus RNA replication by hepatitis delta antigen.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Strain-specific responsiveness of hepatitis D virus to interferon-alpha treatment.JHEP reports : innovation in hepatology · 2023Article
- Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice.Frontiers in microbiology · 2021Article
- Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin.Frontiers in microbiology · 2021Review
- Hepatitis Delta Antigen Regulates mRNA and Antigenome RNA Levels during Hepatitis Delta Virus Replication.Journal of virology · 2019Article
- Article
- Prevalence of hepatitis delta virus (HDV) infection in chronic hepatitis B patients with unusual clinical pictures.Hepatitis monthly · 2013Article
- Phylogenetic analysis of HDV isolates from HBsAg positive patients in Karachi, Pakistan.Virology journal · 2012Article
- Control of ADAR1 editing of hepatitis delta virus RNAs.Current topics in microbiology and immunology · 2012Review
- Multimerization of hepatitis delta antigen is a critical determinant of RNA binding specificity.Journal of virology · 2010Article
- The fraction of RNA that folds into the correct branched secondary structure determines hepatitis delta virus type 3 RNA editing levels.RNA (New York, N.Y.) · 2009Article
- Hepatitis delta antigen requires a minimum length of the hepatitis delta virus unbranched rod RNA structure for binding.Journal of virology · 2009Article
- Eighth major clade for hepatitis delta virus.Emerging infectious diseases · 2006Article
- Effects of conserved RNA secondary structures on hepatitis delta virus genotype I RNA editing, replication, and virus production.Journal of virology · 2005Article
- Molecular evolution of the hepatitis delta virus antigen gene: recombination or positive selection?Journal of molecular evolution · 2004Article
- Interaction and replication activation of genotype I and II hepatitis delta antigens.Journal of virology · 2004Article
- Molecular phylogenetic analyses indicate a wide and ancient radiation of African hepatitis delta virus, suggesting a deltavirus genus of at least seven major clades.Journal of virology · 2004Article
- In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.The Journal of clinical investigation · 2003Article
- Differential inhibition of RNA editing in hepatitis delta virus genotype III by the short and long forms of hepatitis delta antigen.Journal of virology · 2003Article
- Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression.Journal of virology · 2002Article
- A prenylation inhibitor prevents production of infectious hepatitis delta virus particles.Journal of virology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same genotype. The significance of the sequence differences has been unclear but could be responsible for pathogenic variations associated with the different genotypes. Studies of the mechanisms of HDV replication have been limited to cDNA clones from HDV genotype I, which is the most common. To perform a comparative analysis of HDV RNA replication in genotypes I and III, we have obtained a full-length cDNA clone from an HDV genotype III isolate. In transfected Huh-7 cells, the functional roles of the two forms of the viral protein, hepatitis delta antigen (HDAg), in HDV RNA replication are similar for both genotypes I and III; the short form is required for RNA replication, while the long form inhibits replication. For both genotypes, HDAg was able to support replication of RNAs of the same genotype that were mutated so as to be defective for HDAg production. Surprisingly, however, neither genotype I nor genotype III HDAg was able to support replication of such mutated RNAs of the other genotype. The inability of genotype III HDAg to support replication of genotype I RNA could have been due to a weak interaction between the RNA and HDAg. The clear genotype-specific activity of HDAg in supporting HDV RNA replication confirms the original categorization of HDV sequences in three genotypes and further suggests that these should be referred to as types (i.e., HDV-I and HDV-III) rather than genotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.