ArticleJournal of virology1998
Involvement of actin microfilaments in the replication of human parainfluenza virus type 3.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Host cytoskeleton and membrane network remodeling in the regulation of viral replication.Biophysics reports · 2025Article
- Altered gene expression in human brain microvascular endothelial cells in response to the infection of influenza H1N1 virus.Animal diseases · 2022Article
- Curcumin Inhibits Replication of Human Parainfluenza Virus Type 3 by Affecting Viral Inclusion Body Formation.BioMed research international · 2021Article
- Involvement of Actin-Regulating Factor Cofilin in the Inclusion Body Formation and RNA Synthesis of Human Parainfluenza Virus Type 3 via Interaction With the Nucleoprotein.Frontiers in microbiology · 2019Article
- Transmissible gastroenteritis virus and porcine epidemic diarrhoea virus infection induces dramatic changes in the tight junctions and microfilaments of polarized IPEC-J2 cells.Virus research · 2014Article
- Actin filaments disruption and stabilization affect measles virus maturation by different mechanisms.Virology journal · 2013Article
- The potential role of microfilaments in host cells for infection with infectious spleen and kidney necrosis virus infection.Virology journal · 2013Article
- Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking.Traffic (Copenhagen, Denmark) · 2011Article
- Proteomic characterization of influenza H5N1 virus-like particles and their protective immunogenicity.Journal of proteome research · 2011Article
- Mutational analysis reveals a noncontractile but interactive role of actin and profilin in viral RNA-dependent RNA synthesis.Journal of virology · 2009Article
- Cellular proteins in influenza virus particles.PLoS pathogens · 2008Article
- Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits.Journal of virology · 2007Article
- Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes.Journal of virology · 2006Article
- Packaging of actin into Ebola virus VLPs.Virology journal · 2005Article
- RNA viruses redirect host factors to better amplify their genome.Advances in virus research · 2005Article
- Beta-catenin associates with human parainfluenza virus type 3 ribonucleoprotein complex and activates transcription of viral genome RNA in vitro.Gene expression · 2004Article
- Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Mammalian reovirus nonstructural protein microNS forms large inclusions and colocalizes with reovirus microtubule-associated protein micro2 in transfected cells.Journal of virology · 2002Article
- Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules.Journal of virology · 2002Article
- Interferon action against human parainfluenza virus type 3: involvement of a novel antiviral pathway in the inhibition of transcription.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Several studies indicate that paramyxoviruses require a specific cellular factor(s) for transcription of their genomic RNAs. We previously reported that the cellular cytoskeletal protein actin, in its polymeric form, participates in the transcription of human parainfluenza virus type 3 (HPIV3) in vitro. In the present study, we investigated the role of the polymeric form of actin, i.e., the actin microfilaments of the cytoskeletal framework, in the reproduction of HPIV3 in vivo. Pulse-chase labeling analyses indicate that the viral nucleocapsid-associated proteins, NP and P, are present predominantly in the cytoskeletal framework during infection. By in situ hybridization, we found that viral mRNAs and genomic RNA were synthesized from the nucleocapsids that were bound to the cytoskeletal framework. Double immunofluorescent labeling and confocal microscopy of the cytoarchitecture revealed that the viral nucleocapsids are specifically localized on the actin microfilaments. Treatment of cells with the actin-depolymerizing agent, cytochalasin D, resulted in the inhibition of viral RNA synthesis and ribonucleoprotein accumulation. These results strongly suggest that actin microfilaments play an important role in the replication of HPIV3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.