ArticleJournal of virology1998
Glucagon treatment interferes with an early step of duck hepatitis B virus infection.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- The expanding landscape of the glucagon signaling network: mechanisms and outcomes.Endocrinology · 2026Review
- Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.Antiviral research · 2018Review
- Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.Journal of virology · 2007Article
- The role of cells refractory to productive infection in acute hepatitis B viral dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway.Journal of virology · 2003Article
- Nuclear localization of the duck hepatitis B virus capsid protein: detection and functional implications of distinct subnuclear bodies in a compartment associated with RNA synthesis and maturation.Journal of virology · 2003Article
- A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.The Journal of experimental medicine · 2001Article
- Signals for bidirectional nucleocytoplasmic transport in the duck hepatitis B virus capsid protein.Journal of virology · 2001Article
- Envelope protein-mediated down-regulation of hepatitis B virus receptor in infected hepatocytes.Journal of virology · 2001Article
- Intracellular hepadnavirus nucleocapsids are selected for secretion by envelope protein-independent membrane binding.Journal of virology · 2000Article
- Endotoxin stimulates liver macrophages to release mediators that inhibit an early step in hepadnavirus replication.Journal of virology · 2000Article
- A metastable form of the large envelope protein of duck hepatitis B virus: low-pH release results in a transition to a hydrophobic, potentially fusogenic conformation.Journal of virology · 2000Article
- Hepatitis B virus biology.Microbiology and molecular biology reviews : MMBR · 2000Review
- Cellular receptor traffic is essential for productive duck hepatitis B virus infection.Journal of virology · 2000Article
- Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections.Journal of virology · 2000Article
- Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Host cell-virus cross talk: phosphorylation of a hepatitis B virus envelope protein mediates intracellular signaling.Journal of virology · 1998Article
- Avian hepatitis B virus infection is initiated by the interaction of a distinct pre-S subdomain with the cellular receptor gp180.Journal of virology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of glucagon on the establishment of hepadnavirus infection was studied in vitro with the duck hepatitis B virus (DHBV) model. The presence of the peptide hormone throughout infection or starting up to 8 h after virus uptake resulted in a dose-dependent reduction in the levels of intra- and extracellular viral gene products and of secreted virions. Treatment with forskolin or dibutyryl-cyclic AMP, two drugs that also stimulate the cyclic AMP (cAMP) signal transduction pathway, resulted in comparable inhibition, suggesting that the inhibitor effect is related to changes in the activity of protein kinase A. In persistently infected hepatocytes, only a slight, but continuous, decrease in viral replication was observed upon prolonged drug treatment. Time course analysis, including detection of DHBV covalently closed circular (ccc) DNA templates, revealed that glucagon acts late during the establishment of infection, at a time when the virus is already internalized, but before detectable ccc DNA accumulation in the nucleus. These data suggest that nuclear import (and reimport) of DHBV DNA genomes from cytosolic capsids is subject to cAMP-mediated regulation by cellular factors responding to changes in the state of the host cell.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.