ArticleThe EMBO journal1998
In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.Current molecular medicine · 2016Review
- The high mobility group A1 molecular switch: turning on cancer - can we turn it off?Expert opinion on therapeutic targets · 2014Review
- Hitting the bull's eye: targeting HMGA1 in cancer stem cells.Expert review of anticancer therapy · 2014Article
- Genetics: polymorphisms, epigenetics, and something in between.Genetics research international · 2012Article
- Article
- Article
- Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide.The EMBO journal · 2006Article
- Dynamic simulation of active/inactive chromatin domains.Journal of biological physics · 2005Article
- Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Heritable transgene expression pattern imposed onto maize ubiquitin promoter by maize adh-1 matrix attachment regions: tissue and developmental specificity in maize transgenic plants.Plant cell reports · 2004Article
- Synthesis of signals for de novo DNA methylation in Neurospora crassa.Molecular and cellular biology · 2003Article
- The matrix attachment region in the Chinese hamster dihydrofolate reductase origin of replication may be required for local chromatid separation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Modification of position-effect variegation by competition for binding to Drosophila satellites.EMBO reports · 2002Article
- The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegation.Molecular and cellular biology · 2002Article
- Cell-type specificity of short-range transcriptional repressors.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides.The EMBO journal · 2001Article
- Use of matrix attachment regions (MARs) to minimize transgene silencing.Plant molecular biology · 2000Review
- Structural changes induced by binding of the high-mobility group I protein to a mouse satellite DNA sequence.Biophysical journal · 2000Article
- Conserved characteristics of heterochromatin-forming DNA at the 15q11-q13 imprinting center.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scaffold-associated regions (SARs) were studied in Drosophila melanogaster by expressing a synthetic, high-affinity SAR-binding protein called MATH (multi-AT-hook), which consists of reiterated AT-hook peptide motifs; each motif is known to recognize a wide variety of short AT-rich sequences. MATH proteins were expressed specifically in the larval eye imaginal discs by means of the tetracycline-regulated transactivation system and tested for their effect on position effect variegation (PEV). MATH20, a highly potent SAR ligand consisting of 20 AT-hooks, was found to suppress whitemottled 4 variegation. This suppression required MATH20 expression at an early larval developmental stage. Our data suggest an involvement of the high AT-rich SARs in higher order chromatin structure and gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.