ArticleThe EMBO journal1998
Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 116 citations in OpenAlex.
- The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.PLoS genetics · 2012Article
- Article
- An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses.Journal of cell science · 2007Article
- Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.Nucleic acids research · 2007Article
- Article
- Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.Molecular biology of the cell · 2006Article
- Brc1-mediated DNA repair and damage tolerance.Genetics · 2005Article
- Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.The EMBO journal · 2004Article
- Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality.Molecular and cellular biology · 2004Article
- Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells.Molecular and cellular biology · 2004Article
- Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA.PLoS biology · 2003Article
- Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links.Molecular and cellular biology · 2003Article
- A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.The EMBO journal · 2003Article
- Fission yeast Rad26 responds to DNA damage independently of Rad3.BMC genetics · 2003Article
- Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9.The EMBO journal · 2003Article
- Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process.Protein science : a publication of the Protein Society · 2002Article
- A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.Molecular and cellular biology · 2002Article
- Fission yeast Rad26 is a regulatory subunit of the Rad3 checkpoint kinase.Molecular biology of the cell · 2002Article
- Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complex.Molecular biology of the cell · 2001Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The hus1+ gene is one of six fission yeast genes, termed the checkpoint rad genes, which are essential for both the S-M and DNA damage checkpoints. Classical genetics suggests that these genes are required for activation of the PI-3 kinase-related (PIK-R) protein, Rad3p. Using a dominant negative allele of hus1+, we have demonstrated a genetic interaction between hus1+ and another checkpoint rad gene, rad1+. Hus1p and Rad1p form a stable complex in wild-type fission yeast, and the formation of this complex is dependent on a third checkpoint rad gene, rad9+, suggesting that these three proteins may exist in a discrete complex in the absence of checkpoint activation. Hus1p is phosphorylated in response to DNA damage, and this requires rad3+ and each of the other checkpoint rad genes. Although there is no gene related to hus1+ in the Saccharomyces cerevisiae genome, we have identified closely related mouse and human genes, suggesting that aspects of the checkpoint control mechanism are conserved between fission yeast and higher eukaryotes.
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