ArticleThe EMBO journal1998
FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- The Transcription Factors AcuK and AcuM Influence Siderophore Biosynthesis ofJournal of fungi (Basel, Switzerland) · 2024Article
- Article
- Two homologs of the Cat8 transcription factor are involved in the regulation of ethanol utilization in Komagataella phaffii.Current genetics · 2021Article
- Nutritional Heterogeneity AmongFrontiers in microbiology · 2019Article
- Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans.ACS chemical biology · 2018Article
- Tpc1 is an important Zn(II)2Cys6 transcriptional regulator required for polarized growth and virulence in the rice blast fungus.PLoS pathogens · 2017Article
- A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster.Frontiers in microbiology · 2015Article
- FAR1 and FAR2 regulate the expression of genes associated with lipid metabolism in the rice blast fungus Magnaporthe oryzae.PloS one · 2014Article
- Role of carnitine acetyltransferases in acetyl coenzyme A metabolism in Aspergillus nidulans.Eukaryotic cell · 2011Article
- ATP-citrate lyase is required for production of cytosolic acetyl coenzyme A and development in Aspergillus nidulans.Eukaryotic cell · 2010Article
- Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum.BMC microbiology · 2010Article
- MlcR, a zinc cluster activator protein, is able to bind to a single (A/T)CGG site of cognate asymmetric motifs in the ML-236B (compactin) biosynthetic gene cluster.Molecular genetics and genomics : MGG · 2009Article
- Article
- A fungal family of transcriptional regulators: the zinc cluster proteins.Microbiology and molecular biology reviews : MMBR · 2006Review
- Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans.Eukaryotic cell · 2006Article
- Molecular analysis of an inactive aflatoxin biosynthesis gene cluster in Aspergillus oryzae RIB strains.Applied and environmental microbiology · 2006Article
- Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans.Genome biology · 2006Article
- Regulation of fumonisin biosynthesis in Fusarium verticillioides by a zinc binuclear cluster-type gene, ZFR1.Applied and environmental microbiology · 2004Article
- Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae.Current genetics · 2003Review
- Regulation of the acuF gene, encoding phosphoenolpyruvate carboxykinase in the filamentous fungus Aspergillus nidulans.Journal of bacteriology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The facB gene is required for acetate induction of acetamidase (amdS) and the acetate utilization enzymes acetyl-CoA synthase (facA), isocitrate lyase (acuD) and malate synthase (acuE) in Aspergillus nidulans. The facB gene encodes a transcriptional activator with a GAL4-type Zn(II)2Cys6 zinc binuclear cluster DNA-binding domain which is shown to be required for DNA binding. In vitro DNA-binding sites for FacB in the 5' regions of the amdS, facA, acuD and acuE genes have been identified. Mutations in amdS FacB DNA-binding sites affected expression of an amdS-lacZ reporter in vivo and altered the affinity of in vitro DNA binding. This study shows that the FacB Zn(II)2Cys6 cluster binds to dissimilar sites which show similarity in form but not sequence with DNA-binding sites of other Zn(II)2Cys6 proteins. Sequences with homology to FacB sites are found in the 5' regions of genes regulated by the closely related yeast Zn(II)2Cys6 protein CAT8.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.